NSE and S100β as serum alarmins in predicting neurological outcomes after cardiac arrest

被引:0
|
作者
Hu, Jiyun [1 ,2 ]
Ai, Meilin [1 ,2 ]
Xie, Shucai [1 ,2 ]
Qian, Zhaoxin [1 ,2 ]
Zhang, Lina [1 ,2 ]
Huang, Li [1 ,2 ]
机构
[1] Cent South Univ, Xiangya Hosp, Hunan Prov Clin Res Ctr Crit Care Med, Dept Crit Care Med, Changsha 410008, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China
来源
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
基金
中国国家自然科学基金;
关键词
Cardiac arrest; CPC Scale; NSE; S100; beta; Prognosis; Neurological outcomes; Continuous monitoring; EUROPEAN RESUSCITATION COUNCIL; CARE MEDICINE GUIDELINES; NEURON-SPECIFIC ENOLASE; BRAIN-INJURY; BIOMARKERS; SOCIETY;
D O I
10.1038/s41598-024-76979-6
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cardiac arrest (CA) is a serious health concern that often results in mortality or severe neurological dysfunction in the case of survival. Our aim was to explore the neurological prognostic factors in patients with CA. This retrospective observational study included adult patients with CA. We investigated serum neuron-specific enolase (NSE), S100 calcium-binding protein beta (S100 beta), and indices and parameters at 1, 3, 5, 7 and intensive care unit (ICU) discharge days after CA. The primary study endpoint was the Cerebral Performance Category (CPC) scale score at ICU discharge, which was dichotomized as good neurological outcome (CPC 1-2: full recovery or moderate disability) and poor neurological outcome (CPC 3-5: severe disability, vegetative state, or death). Of the 191 adult patients with CA, 42 (22%) had good neurological outcomes, and 149 (78%) had poor neurological outcomes. NSE at 1,3,5,7 and ICU discharge days showed excellent predictive accuracy for neurological outcomes (area under the curve [AUC]: 0.666, 0.716, 0.870, 0.739, and 0.901, respectively). However, S100 beta exhibited general predictive power (AUC: 0.666, 0.573, 0.607, 0.594, 0.727). Finally, the early warning model, which combined day 1 NSE, day 1 S100 beta, cardiac arrest time, SOFA scores, APACHE II scores, and age, was used to screen CA patients with poor neurological prognosis at early stages and had an AUC of 0.792. Serum concentrations of NSE and S100 beta were significantly elevated in CA patients and could be prognostic biomarkers to predict neurological outcomes. Day 1 NSE and S100 beta combined with multiple indicators could be a decent early warning model for poor neurological prognosis in patients with CA.
引用
收藏
页数:10
相关论文
共 50 条
  • [1] Accuracy of Serum NSE and S-100 Protein in Predicting Outcome After Cardiac Arrest
    Mlynash, Michael
    Caulfield, Anna Finley
    Eyngorn, Irina
    Buckwalter, Marion S.
    Wijman, Christine A.
    STROKE, 2010, 41 (04) : E307 - E307
  • [2] NSE and S-100 protein as early predictors for neurological outcome after cardiac arrest
    Uray, T
    Haugk, M
    Holzer, M
    Sterz, F
    Frossard, M
    Losert, H
    Kliegel, A
    Spitzauer, S
    Laggner, AN
    CIRCULATION, 2004, 110 (17) : 453 - 453
  • [3] Serum S100β as a predictor of neurologic and neurocognitive outcomes after cardiac surgery
    Grocott, HP
    Croughwell, ND
    Verkerk, GC
    Amory, DW
    White, WD
    Kirchner, J
    Newman, MF
    ANESTHESIA AND ANALGESIA, 1998, 86 (2S): : U57 - U57
  • [4] Modeling Serum Level of S100β and Bispectral Index to Predict Outcome After Cardiac Arrest
    Stammet, Pascal
    Wagner, Daniel R.
    Gilson, Georges
    Devaux, Yvan
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 62 (09) : 851 - 858
  • [5] Predicting neurological outcome after cardiac arrest and hypothermic treatment by NSE (Neuron Specific Enolase)
    Schratter, A.
    Pittl, U.
    Lehmann, D.
    Demmin, K.
    Klemm, T.
    Schuler, G.
    Mende, M.
    Thiele, H.
    EUROPEAN HEART JOURNAL, 2010, 31 : 899 - 900
  • [6] Hyperglycaemia increases S100β after short experimental cardiac arrest
    Molnar, M.
    Bergquist, M.
    Larsson, A.
    Wiklund, L.
    Lennmyr, F.
    ACTA ANAESTHESIOLOGICA SCANDINAVICA, 2014, 58 (01) : 106 - 113
  • [7] NSE and S100 after hypoxia in the newborn pig
    Kecskes, Z
    Dunster, KR
    Colditz, PB
    PEDIATRIC RESEARCH, 2005, 58 (05) : 953 - 957
  • [8] NSE and S100 after Hypoxia in the Newborn Pig
    Zsuzsoka Kecskes
    Kimble R Dunster
    Paul B Colditz
    Pediatric Research, 2005, 58 : 953 - 957
  • [9] Predicting neurological outcome after cardiac arrest
    Oddo, Mauro
    Rossetti, Andrea O.
    CURRENT OPINION IN CRITICAL CARE, 2011, 17 (03) : 254 - 259
  • [10] Analysis of subunits S100AIB and S100BB in comparison with the total amount of S100 in serum after cardiac arrest
    Rosén, H
    Hall, C
    Nilsson, O
    Rosengren, L
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2005, 238 : S520 - S520