With the proliferation of spatio-textual data, Top-k KNN spatial keyword queries (TkQs), which return a list of objects based on a ranking function that considers both spatial and textual relevance, have found many real-life applications. To efficiently handle TkQs, many indexes have been developed, but the effectiveness of TkQ is limited. To improve effectiveness, several deep learning models have recently been proposed, but they suffer severe efficiency issues and there are no efficient indexes specifically designed to accelerate the top-k search process for these deep learning models. To tackle these issues, we consider embedding based spatial keyword queries, which capture the semantic meaning of query keywords and object descriptions in two separate embeddings to evaluate textual relevance. Although various models can be used to generate these embeddings, no indexes have been specifically designed for such queries. To fill this gap, we propose LIST, a novel machine learning based Approximate Nearest Neighbor Search index that Learns to Index the Spatio-Textual data. LIST utilizes a new learning-to-cluster technique to group relevant queries and objects together while separating irrelevant queries and objects. There are two key challenges in building an effective and efficient index, i.e., the absence of high-quality labels and the unbalanced clustering results. We develop a novel pseudo-label generation technique to address the two challenges. Additionally, we introduce a learning based spatial relevance model that can integrate with various text relevance models to form a lightweight yet effective relevance for reranking objects retrieved by LIST. Experimental results show that (1) our lightweight embedding based relevance model significantly outperforms state-of-the-art relevance models; (2) LIST outperforms state-of-the-art indexes, providing a better trade-off between effectiveness and efficiency.