Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization

被引：0

作者：

Syed A. H. Zaidi ^{[1
]}

Ruth B. Caldwell ^{[2
]}

Modesto A. Rojas ^{[3
]}

机构：

[1] Augusta University,Vascular Biology Center

[2] Augusta University,Vision Discovery Institute

[3] Augusta University,Department of Medicine

[4] Augusta University,Department of Cellular Biology and Anatomy

[5] Augusta University,Department of Pharmacology and Toxicology

来源：

npj Metabolic Health and Disease | / 3卷 / 1期

关键词：

D O I：

10.1038/s44324-024-00046-x

中图分类号：

学科分类号：

摘要：

Pathological retinal neovascularization (RNV) is a major cause of vision loss and blindness during ischemic retinopathies. Our investigations in the mouse model of oxygen-induced retinopathy (OIR) demonstrate a novel mechanism of pathological RNV and neurovascular injury. We show that OIR-induced activation of macrophage/microglial cells, retinal inflammation, and pathological RNV are mediated by increases in cholesterol ester (CE) formation due to activation of the acyl-CoA: Cholesterol Acyltransferase 1/Sterol O-Acyltransferase 1 (ACAT1/SOAT1) enzyme.

引用

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