Cardiorespiratory Fitness and Sleep, but not Physical Activity, are Associated with Functional Connectivity in Older Adults

被引:0
|
作者
Wing, David [1 ,2 ]
Roelands, Bart [6 ,10 ]
Wetherell, Julie Loebach [4 ,5 ]
Nichols, Jeanne F. [1 ,2 ]
Meeusen, Romain [6 ,10 ,11 ]
Godino, Job G. [1 ,2 ]
Shimony, Joshua S. [9 ]
Snyder, Abraham Z. [9 ]
Nishino, Tomoyuki [3 ]
Nicol, Ginger E. [3 ]
Nagels, Guy [8 ]
Eyler, Lisa T. [5 ,7 ]
Lenze, Eric J. [3 ]
机构
[1] Univ Calif San Diego, Herbert Wertheim Sch Publ Hlth & Human Longev Sci, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Exercise & Phys Act Resource Ctr EPARC, La Jolla, CA 92093 USA
[3] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO USA
[4] VA San Diego Healthcare Syst, Mental Hlth Serv, San Diego, CA USA
[5] Univ Calif San Diego, Dept Psychiat, La Jolla, CA USA
[6] Vrije Univ Brussel, Fac Phys Educ & Physiotherapy, Human Physiol & Sports Physiotherapy Res Grp, Brussels, Belgium
[7] San Diego Vet Adm Healthcare Syst, Educ & Clin Ctr, Desert Pacific Mental Illness Res, San Diego, CA USA
[8] Vrije Univ Brussel VUB, UZ Brussel, Ctr Neurosci C4N, Dept Neurol, Brussels, Belgium
[9] Washington Univ, Mallinckrodt Inst Radiol, Sch Med, St Louis, MO USA
[10] Vrije Univ Brussel, Brussels, Belgium
[11] Univ Western Cape, Dept Sports Recreat Exercise & Sci Community & Hlt, Cape Town, South Africa
关键词
Functional connectivity; Brain health; Maximal cardiovascular fitness; Successful aging; Physical activity; Body composition; Sleep quality; Sleep quantity; BODY-MASS INDEX; COGNITIVE FUNCTION; ACTIVITY MONITORS; BRAIN CONNECTIVITY; DEFAULT NETWORK; RISK; AGE; EXERCISE; PERFORMANCE; DURATION;
D O I
10.1186/s40798-024-00778-6
中图分类号
G8 [体育];
学科分类号
04 ; 0403 ;
摘要
BackgroundAging results in changes in resting state functional connectivity within key networks associated with cognition. Cardiovascular function, physical activity, sleep, and body composition may influence these age-related changes in the brain. Better understanding these associations may help clarify mechanisms related to brain aging and guide interventional strategies to reduce these changes.MethodsIn a large (n = 398) sample of healthy community dwelling older adults that were part of a larger interventional trial, we conducted cross sectional analyses of baseline data to examine the relationships between several modifiable behaviors and resting state functional connectivity within networks associated with cognition and emotional regulation. Additionally, maximal aerobic capacity, physical activity, quality of sleep, and body composition were assessed. Associations were explored both through correlation and best vs. worst group comparisons.ResultsGreater cardiovascular fitness, but not larger quantity of daily physical activity, was associated with greater functional connectivity within the Default Mode (p = 0.008 r = 0.142) and Salience Networks (p = 0.005, r = 0.152). Better sleep (greater efficiency and fewer nighttime awakenings) was also associated with greater functional connectivity within multiple networks including the Default Mode, Executive Control, and Salience Networks. When the population was split into quartiles, the highest body fat group displayed higher functional connectivity in the Dorsal Attentional Network compared to the lowest body fat percentage (p = 0.011; 95% CI - 0.0172 to - 0.0023).ConclusionThese findings confirm and expand on previous work indicating that, in older adults, higher levels of cardiovascular fitness and better sleep quality, but not greater quantity of physical activity, total sleep time, or lower body fat percentage are associated with increased functional connectivity within key resting state networks.
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页数:16
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