Prospective association of daily toothbrushing frequency and the prevalence of childhood functional constipation: the Japan Environment and Children's Study

被引：0

作者：

Tsuchiya, Masahiro ^{[1
]}

Tsuchiya, Shinobu ^{[2
,3
]}

Momma, Haruki ^{[4
]}

Nagatomi, Ryoichi ^{[5
]}

Yaegashi, Nobuo ^{[6
,7
]}

Arima, Takahiro ^{[8
]}

Ota, Chiharu ^{[7
,8
,9
]}

Igarashi, Kaoru ^{[2
,3
]}

Miura, Yuichiro ^{[10
]}

Japan Environm Childrens Study Grp, Michihiro

Kamijima, Michihiro ^{[11
]}

Yamazaki, Shin ^{[12
]}

Ohya, Yukihiro ^{[13
]}

Kishi, Reiko ^{[14
]}

Hashimoto, Koichi ^{[15
]}

Mori, Chisato ^{[16
]}

Ito, Shuichi ^{[17
]}

Yamagata, Zentaro ^{[18
]}

Inadera, Hidekuni ^{[19
]}

Nakayama, Takeo ^{[20
]}

Sobue, Tomotaka ^{[21
]}

Shima, Masayuki ^{[22
]}

Kageyama, Seiji ^{[23
]}

Suganuma, Narufumi ^{[24
]}

Ohga, Shoichi ^{[25
]}

Katoh, Takahiko ^{[26
]}

机构：

[1] Tohoku Fukushi Univ, Dept Nursing, 6-149-1 Kunimi Ga Oka,Aoba Ku, Sendai, Miyagi 9813201, Japan

[2] Tohoku Univ, Grad Sch Dent, Grad Sch Dent, Sendai, Japan

[3] Tohoku Univ Hosp, Dept Orthodont & Speech Therapy Craniofacial Anoma, Sendai, Japan

[4] Tohoku Univ, Grad Sch Med, Dept Med & Sci Sports & Exercise, Sendai 9808575, Japan

[5] Tohoku Univ, Designing Future Hlth Initiat DFHI, Promot Off Strateg Innovat, Sendai, Japan

[6] Tohoku Univ, Grad Sch Med, Dept Obstet & Gynecol, Sendai 9808575, Japan

[7] Tohoku Univ, Grad Sch Med, Dept Dev & Environm Med, Sendai 9808575, Japan

[8] Tohoku Univ, Grad Sch Med, Environm & Genome Res Ctr, Dept Informat Genet, Sendai 9808575, Japan

[9] Tohoku Univ Hosp, Dept Pediat, Sendai 9808574, Japan

[10] Tohoku Univ, Dept Fetomaternal Med Sci, Grad Sch Med, Aoba Ward, 2-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan

[11] Nagoya City Univ, Nagoya, Japan

[12] Natl Inst Environm Studies, Tsukuba, Japan

[13] Natl Ctr Child Hlth & Dev, Tokyo, Japan

[14] Hokkaido Univ, Sapporo, Japan

[15] Fukushima Med Univ, Fukushima, Japan

[16] Chiba Univ, Chiba, Japan

[17] Yokohama City Univ, Yokohama, Japan

[18] Univ Yamanashi, Chuo, Japan

[19] Univ Toyama, Toyama, Japan

[20] Kyoto Univ, Kyoto, Japan

[21] Osaka Univ, Suita, Japan

[22] Hyogo Med Univ, Nishinomiya, Japan

[23] Tottori Univ, Yonago, Japan

[24] Kochi Univ, Nankoku, Japan

[25] Kyushu Univ, Fukuoka, Japan

[26] Kumamoto Univ, Kumamoto, Japan

来源：

SCIENTIFIC REPORTS | 2025年 / 15卷 / 01期

关键词：

BOWEL; EPIDEMIOLOGY; MICROBIOME; BEHAVIOR;

D O I：

10.1038/s41598-025-88562-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Functional constipation is the most common gastrointestinal disorder during childhood. Oral stimulation (mastication and toothbrushing) reportedly improves bowel movements, but the association between daily toothbrushing behavior and functional constipation remains unknown. Data (n = 83,660) from fetal records (n = 104,059) in the Japan Environment and Children's Study, an ongoing prospective birth cohort, were analyzed to investigate the impact of daily toothbrushing frequency on functional constipation during childhood, using ROME III diagnostic criteria. After multiple imputations of data acquired from self-reported questionnaires, a multivariable binomial logistic regression analysis was used with adjustments for several maternal and child-related variables. Functional constipation was observed in 10,123 (12.1%) and 8,820 (10.5%) participants at 3 and 4 years postpartum, respectively. Using the appropriate frequency of daily toothbrushing (twice or more) as a reference, the odds of functional constipation increased with decreasing daily toothbrushing frequency after covariate adjustments involving daily feeding frequency. The adjusted odds ratio (OR) for functional constipation in participants without daily toothbrushing behavior (less than once a day) at 4 years postpartum was 1.87 (95% confidence interval [CI] 1.34-2.61). Similarly, the adjusted OR (95% CI) for chronic functional constipation (at both 3 and 4 years postpartum) in participants without daily toothbrushing behavior (less than once a day) at 2 years postpartum was 1.62 (1.14-2.31). Functional constipation during childhood was associated with decreased daily toothbrushing frequency. Although the underlying mechanism of daily toothbrushing behavior in prompting bowel movements remains unclear, it is a major basis of self-health management in children that plays an important role in managing functional constipation.

引用

页数：8

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