BaTiO3 Doping Enhances Ultrasound-Driven Piezoelectric Bactericidal Effects of Fibrous Poly(<sc>L</sc>-Lactic Acid) Dressings to Accelerate Septic Wound Healing

被引：1

作者：

Wu, Liping ^{[1
,2
,3
]}

Lu, Yanhui ^{[2
,3
]}

Liu, Lulu ^{[4
]}

Wang, Jianfeng ^{[5
]}

Bai, Yunyang ^{[4
,6
,7
]}

Song, Jia ^{[4
]}

Heng, Boon Chin ^{[2
,3
,6
,7
]}

Wu, Tingting ^{[8
]}

Ren, Qiaomei ^{[8
]}

Li, Tingjun ^{[8
]}

Xu, Mingming ^{[4
,6
,7
]}

Deng, Xuliang ^{[1
,4
,6
,7
]}

He, Ying ^{[4
,6
,7
]}

Liu, Yang ^{[2
,3
,6
,7
,8
]}

Zhang, Xuehui ^{[1
,2
,3
,6
,7
,8
]}

机构：

[1] Peking Univ, Inst Med Technol, Hlth Sci Ctr, Beijing 100191, Peoples R China

[2] Peking Univ, Sch & Hosp Stomatol, Dept Dent Mat, Beijing 100081, Peoples R China

[3] Peking Univ, Sch & Hosp Stomatol, Dent Med Devices Testing Ctr, Beijing 100081, Peoples R China

[4] Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China

[5] Jilin Univ, Coll Vet Med, State Key Lab Zoonot Dis, Key Lab Zoonosis Res,Minist Educ, Changchun 130012, Peoples R China

[6] Peking Univ, Sch & Hosp Stomatol, Natl Engn Res Ctr Oral Biomat & Digital Med Device, Beijing Lab Biomed Mat,NMPA Key Lab Dent Mat,Natl, Beijing 100081, Peoples R China

[7] Peking Univ, Sch & Hosp Stomatol, Beijing Key Lab Digital Stomatol, Beijing 100081, Peoples R China

[8] First Peoples Hosp Jinzhong, Oral Translat Med Res Ctr, Shanxi Key Lab Oral & Maxillofacial Repair, Reconstruct & Regenerat Joint Training Base, Jinzhong 030600, Shanxi, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2024年 / 16卷 / 49期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

piezoelectric response; ultrasound-driven; antibacterial; infectedwound healing; electrospunfibrous dressing; MITOCHONDRIA;

D O I：

10.1021/acsami.4c17407

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Bacterial invasion in infected skin wounds triggers inflammation and impedes healing. Current therapeutic strategies incorporating drug interventions within wound dressings often result in drug resistance and delayed healing. Here, we developed a comprehensive therapeutic modality integrating piezoelectric fibrous dressing with controlled ultrasound stimulation for efficient healing in an infected wound model. The electrospun fibrous dressings composed of barium titanate (BaTiO3) doped poly(L-lactic acid) (PLLA) possess improved piezoelectric properties due to the aligned structure and high crystallinity, which achieved superior bactericidal efficacy upon ultrasound-mechanical-electric conversion that results in the production of reactive oxygen species (ROS). There were 88.72% and 90.43% killing rates of Staphylococcus aureus and Escherichia coli respectively upon ultrasound stimulation without any need for exogenous drugs, and a wound closure rate of 95.5% within 10 days. The in vivo results confirmed that this dressing effectively shortened wound closure time by about 2 days, with a much-improved healing rate of 14% compared with previously reported therapeutic strategies. This was accompanied by reduced inflammation and increased re-epithelialization and angiogenesis. Hence, our synergistic treatment by piezoelectric materials and controlled ultrasound stimulation provides a drug-free alternative approach in regenerative tissue engineering for simultaneously enhancing antibacterial effects and promoting wound healing.

引用

页码：67477 / 67490

页数：14