Catheter ablation of atrial fibrillation in elderly population

Background Although elderly patients have been included in published series of catheter ablation for atrial fibrillation（AF）, clinical benefit and safety remain still less defined in this population. A retrospective analysis of the results of catheter ablation for AF in a large volume center focused on comparison of elderly patients with the rest of the patient cohort was conducted in this study. Methods Consecutive patients who underwent catheter ablation for AF between January 2001 and December 2016 were analysed. A total population of 3197 patients was dichotomized by the age of 70 years（394 elderly vs. 2803 younger subjects）. Patients were followed in terms of arrhythmia status and survival for a median period of 18 vs. 21 and 35 vs. 57 months, respectively. Results Elderly patients were more frequently females（49% vs.29%, P < 0.0001）, had a history of hypertension（79% vs. 57%, P < 0.0001）, diabetes（16% vs. 11%, P < 0.01）, stroke（9% vs. 6%, P < 0.01）,coronary/peripheral artery disease（14% vs. 8%, < 0.0001）, and CHA2 DS2-VASc score（3.1 ± 1.3 vs. 1.5 ± 1.2 s, P < 0.0001）. Major complications were more frequent in elderly（5.3% vs. 3.2%, P = 0.03）; however, this difference was driven by vascular complications（3.6% vs.1.9%, P = 0.04）. There were comparable rates of cerebrovascular（0.3 vs. 0.3%） or nonvascular complications（1.8 vs. 1.2%）. Good arrhythmia control was inferior in elderly patients as compared with the rest of the cohort, both without and with antiarrhythmic drugs: 44.2% vs.58.2%（P < 0.0001） and 78.2 vs. 83.2%（P < 0.01）, respectively. Poor arrhythmia control was associated with relative risk of all-cause mortality of 2.7（95% CI: 1.1-6.4） in elderly patients and 1.4（95% CI: 0.9-2.0） in younger subjects. Conclusions Catheter ablation for AF in elderly patients is safe although somewhat less effective. Good arrhythmia control is associated with better survival, especially in elderly patients.