Regularizing the discrete ill-posed inverse problem of electrocardiography

In this study, the generalized singular value decomposition was used to derived the L-curve method in combination with the Tikhonov regularization for solving the discrete ill-posed inverse problem in electrocardiography. We used a boundary element model of the torso and epicardial surface. We validated the inverse solution for a single dipolar source and for the oblique dipoles generated by an anatomatically accurate model of the human ventricular myocardium. We have demonstrated that our inverse solution can be used for accurately localizing the preexcitation sites in patients suffering from Wolff-Parkinson-White syndrome.