Regioselective synthesis of C-nucleosides by 1,3-dipolar cycloaddition of arylnitrile oxides to 5,6-dideoxy-1,2-O-iso-propylidene-α-D-xylo-hex-enofuranose

被引：0
|
作者：
Al-Timari, U.A.R. [1 ]
Fisera, L. [1 ]
机构：
[1] Department of Organic Chemistry, Slovak Technical University, CS-81237 Bratislava, Czechoslovakia
来源：
Carbohydrate Research | 1991年 / 218卷
关键词：
Drug Products - Antibiotics - Organic Compounds - Physical Properties - Sugars - Addition Reactions;
D O I：
10.1016/0008-6215(91)84091-R
中图分类号：
学科分类号：
摘要：
The synthesis of 3-aryl-5-(1,2-O-isopropylidene-α- D-xylo-tetrofuranos-4-yl) -2-isoxazoline (3) from arylnitrile oxides and 5,6-dideoxy-1,2-O-isopropyl- idene-α-D-xylo-hex-5-enofuranose (1) is described. The 1,3-dipolar cycloaddition reactions give mainly anti-adducts (≥ 95% π-facial stereoselectivity).
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页码：121 / 127
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