Radiation induced decomposition of tryptophan in the presence of oxygen

被引：0
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作者：
Josimovic, L. [1 ]
Jankovic, I. [1 ]
Jovanovic, S.V. [1 ]
机构：
[1] Laboratory of Solid Phase Physics, and Radiation Chemistry, Boris Kidric Inst. of Nuclear Scis., P.O. Box 522, 11001 Beograd, Yugoslavia
来源：
Radiation Physics and Chemistry | 1993年 / 41卷 / 06期
关键词：
Amino acids - Decomposition - Electron beams - Free radical reactions - Free radicals - Gamma rays - Oxygen - Peroxides - Pigments - Radiation effects - Reaction kinetics - Solutions;
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摘要：
Tryptophan decomposition in oxygenated aqueous solutions in neutral media was investigated by gamma and pulsed electron irradiation. By using pulse radiolysis it was found that 27% of tryptophan OH-adducts eliminate water. Tryptophan neutral radical, Trp, thus formed reacts rapidly with O2-&middot, k(Trp&middot+O2-&middot) = (4.5± 0.7)×109M-1s-1. The remaining tryptophan OH-adducts react with oxygen to give peroxy radicals which may eliminate O2-&middot, produce N-formylkynurenine and disproportionate yielding organic peroxides. Peroxy radicals derived from tryptophan H-adducts regenerate tryptophan by the elimination of HO2&middot, and recombine with TrpH(OH)OO&middot radicals producing organic peroxides.
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页码：835 / 841
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