High-throughput approaches to the quantitative analysis of ketoconazole, a potent inhibitor of cytochrome P450 3A4, in human plasma

被引：0
|
作者：
Ramos, L. [1 ]
Brignol, N. [1 ]
Bakhtiar, R. [1 ,2 ]
Ray, T. [1 ]
Mc Mahon, L.M. [1 ]
Tse, F.L.S. [1 ]
机构：
[1] Department of Drug Metabolism and Pharmacokinetics, Novartis Institute for Biomedical Research, East Hanover, NJ 07936, United States
[2] Novartis Pharmaceuticals Corporation, 59 Route 10, East Hanover, NJ 07936, United States
来源：
| 2000年 / John Wiley and Sons Ltd卷 / 14期
关键词：
Antimycotic agent - Cytochrome P450-3A4 - High-throughput approaches - Human plasmas - Imidazol - Isoforms - Orally active - Potent inhibitor - Sample preparation - Specific inhibitors;
D O I：
10.1002/1097-0231(20001215)14:233.0.CO;2-V
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