Synthesis and anti-HIV activity of some novel chain-extended phosphoramidate derivatives of d4T (stavudine): esterase hydrolysis as a rapid predictive test for antiviral potency

被引:0
|
作者
机构
来源
Antiviral Chem Chemother | / 2卷 / 109期
关键词
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 20 条
  • [1] Synthesis and anti-HIV activity of some novel chain-extended phosphoramidate derivatives of d4T (stavudine): esterase hydrolysis as a rapid predictive test for antiviral potency
    McGuigan, C
    Tsang, HW
    Sutton, PW
    De Clercq, E
    Balzarini, J
    ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1998, 9 (02): : 109 - 115
  • [2] Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T)
    McGuigan, C
    Sutton, PW
    Cahard, D
    Turner, K
    O'Leary, G
    Wang, Y
    Gumbleton, M
    De Clercq, E
    Balzarini, J
    ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1998, 9 (06): : 473 - 479
  • [3] Polyfluoroaromatic stavudine (d4T) ProTides exhibit enhanced anti-HIV activity
    Kandil, Sahar
    Pannecouque, Christophe
    Chapman, Fiona M.
    Westwell, Andrew D.
    McGuigan, Christopher
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 29 (24)
  • [4] One-pot synthesis of aryl phosphoramidate derivatives of AZT/d4T as anti-HIV prodrugs
    Jiang, P
    Guo, J
    Fu, H
    Jiang, YY
    Zhao, YF
    SYNLETT, 2005, (16) : 2537 - 2539
  • [5] Anti-HIV activity of novel phosphonate derivatives of AZT, d4T, and ddA
    Pokrovsky, AG
    Pronayeva, TR
    Fedyuk, NV
    Shirokova, EA
    Khandazhinskaya, AL
    Tarusova, NB
    Karpenko, IL
    Krayevsky, AA
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2001, 20 (4-7): : 767 - 769
  • [6] Synthesis and in vitro enzymatic and antiviral evaluation of phosphoramidate d4T derivatives as chain terminators
    Yang, Shiqiong
    Pannecouque, Christophe
    Lescrinier, Eveline
    Girauta, Anne
    Herdewijn, Piet
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, 10 (01) : 146 - 153
  • [7] New and efficient approach to aryl phosphoramidate derivatives of AZT/d4T as anti-HIV prodrugs
    Li, XS
    Fu, H
    Jiang, YY
    Zhao, YF
    Liu, JY
    SYNLETT, 2004, (14) : 2600 - 2602
  • [8] A QSAR study investigating the effect of L-alanine ester variation on the anti-HIV activity of some phosphoramidate derivatives of d4T
    Knaggs, MH
    McGuigan, C
    Harris, SA
    Heshmati, P
    Cahard, D
    Gilbert, IH
    Balzarini, J
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (18) : 2075 - 2078
  • [9] Phosphoramidate derivatives of d4T with improved anti-HIV efficacy retain full activity in thymidine kinase-deficient cells
    McGuigan, C
    Cahard, D
    Sheeka, HM
    DeClercq, E
    Balzarini, J
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (10) : 1183 - 1186
  • [10] Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite
    McGuigan, C
    Cahard, D
    Sheeka, HM
    DeClercq, E
    Balzarini, J
    JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (08) : 1748 - 1753