Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: Three new products generated in the mithramycin producer streptomyces argillaceus through combinatorial biosynthesis

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[1] Remsing, Lily L.
[2] González, Ana M.
[3] Nur-e-Alam, Mohammad
[4] Fernández-Lozano, M. José
[5] Braña, Alfredo F.
[6] Rix, Uwe
[7] Oliveira, Marcos A.
[8] Méndez, Carmen
[9] Salas, José A.
[10] Rohr, Jürgen
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Salas, J.A. (jrohr2@uky.edu) | 1600年 / American Chemical Society卷 / 125期
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  • [1] Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK:: Three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis
    Remsing, LL
    González, AM
    Nur-e-Alam, M
    Fernández-Lozano, MJ
    Braña, AF
    Rix, U
    Oliveira, MA
    Méndez, C
    Salas, JA
    Rohr, J
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (19) : 5745 - 5753
  • [2] Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway
    Remsing, LL
    Garcia-Bernardo, J
    Gonzalez, A
    Künzel, E
    Rix, U
    Braña, AF
    Bearden, DW
    Méndez, C
    Salas, JA
    Rohr, J
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (08) : 1606 - 1614
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