Process intensification: Nano-carrier formation by a continuous dense gas process

被引：0
|
作者：
Beh, Chau Chun [1 ]
Mammucari, Raffaella [1 ]
Foster, Neil R. [1 ]
机构：
[1] School of Chemical Engineering, UNSW Australia, Australia
来源：
Chemical Engineering Journal | 2015年 / 266卷
关键词：
Formation of nano-carriers such as vesicles and micelles using dense gas processing has been under extensive research for decades. Several dense gas processes have been developed to produce nano-carriers; most of them being batch processes. In the present study; a novel continuous dense gas; known as nano-carrier by a continuous dense gas (NADEG) process was developed as an evolution of a dense gas batch process known as the Depressurization of an Expanded Solution into Aqueous Media (DESAM) process. Transforming a batch process into a continuous process is a main aspect of process intensification. The NADEG process developed in this work enhances the production output of the batch process while producing nano-carriers free of harmful residual organic solvent. The NADEG process is a one-step process for the production of nano-carriers with lower size and higher encapsulation efficiency than the nano-carriers produced by other batch processes. Encapsulation efficiencies as high as 15% were achieved using liposomes to encapsulate a model hydrophilic compound (isoniazid) while encapsulation efficiencies of 10% were achieved in polymersomes for the same model compound. © 2015 Elsevier B.V;
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页码：320 / 328
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