Cleavage of four carbon-carbon bonds during biosynthesis of the griseorhodin a spiroketal pharmacophore

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作者
Yunt, Zeynep [1 ]
Reinhardt, Kathrin [1 ]
Li, Aiying [2 ,6 ]
Engeser, Marianne [1 ]
Dahse, Hans-Martin [3 ]
Gütschow, Michael [4 ]
Bruhn, Torsten [5 ]
Bringmann, Gerhard [5 ]
Piel, Jörn [1 ]
机构
[1] Kekulé Institute of Organic Chemistry and Biochemistry, Pharmaceutical Institute, University of Bonn, 53121 Bonn, Germany
[2] Department of Bioorganic Chemistry, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany
[3] Department of Infection Biology Germany, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoll Institute, 07745 Jena, Germany
[4] Pharmaceutical Institute, University of Bonn, 53121 Bonn, Germany
[5] Institute of Organic Chemistry, University of Würzburg, 97074 Würzburg, Germany
[6] College of Life Sciences, Central China Normal University, Wuhan 430079, China
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Biochemistry - Gene expression - Aromatic compounds - Carbon - Covalent bonds - Quantum chemistry - Dichroism - Ketones - Bacteria - Pharmacodynamics;
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Journal article (JA)
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页码:2297 / 2305
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