Fatigue-Related Changes of Daily Function: Most Promising Measures for the Digital Age

被引：1

作者：

Maetzler W. ^{[1
]}

Correia Guedes L. ^{[2
]}

Emmert K.N. ^{[1
]}

Kudelka J. ^{[1
]}

Hildesheim H.L. ^{[1
]}

Paulides E. ^{[3
]}

Connolly H. ^{[4
]}

Davies K. ^{[5
]}

Dilda V. ^{[6
]}

Ahmaniemi T. ^{[7
]}

Avedano L. ^{[8
]}

Bouça-Machado R. ^{[2
]}

Chambers M. ^{[9
]}

Chatterjee M. ^{[10
]}

Gallagher P. ^{[11
]}

Graeber J. ^{[12
]}

Maetzler C. ^{[1
]}

Kaduszkiewicz H. ^{[12
]}

Kennedy N. ^{[4
]}

Macrae V. ^{[5
]}

Carrasco Marín L. ^{[13
]}

Moses A. ^{[4
,14
]}

Padovani A. ^{[15
]}

Pilotto A. ^{[15
]}

Ratcliffe N. ^{[16
]}

Reilmann R. ^{[17
,18
,19
]}

Rosario M. ^{[2
]}

Schreiber S. ^{[20
]}

De Sousa D. ^{[21
]}

Van Gassen G. ^{[22
]}

Warring L.A. ^{[23
]}

Seppi K. ^{[24
]}

Van Der Woude C.J. ^{[3
]}

Ferreira J.J. ^{[2
]}

Ng W.-F. ^{[5
]}

机构：

[1] Department of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel and Kiel University, Kiel

[2] Instituto de Medicina Molecular João Lobo Antunes and Centro de Estudos Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Lisbon

[3] Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam

[4] School of Allied Health, Faculty of Education and Health Sciences and Health Research Institute, University of Limerick, Limerick

[5] Translational and Clinical Research Institute, Newcastle University and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne

[6] CHDI Management, CHDI Foundation, Princeton, NJ

[7] Teknologian Tutkimuskeskus VTT Oy, Espoo

[8] European Federation of Crohn's and Ulcerative Colitis, Brussels

[9] MC Healthcare Evaluation, London

[10] Janssen Research and Development, Cambridge, MA

[11] Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne

[12] Institute of General Medicine, University Medical Centre Schleswig-Holstein, Kiel University, Kiel

[13] Asociación Parkinson Madrid, Madrid

[14] University of Twente, Department of Medical Cell Biophysics, TechMed Centre, Enschede

[15] Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia

[16] Parkinson's UK, London

[17] George-Huntington-Institute, R&D-Campus/Technology-Park Münster, Münster

[18] Institute of Clinical Radiology, University of Münster, Münster

[19] Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen

[20] Department of Internal Medicine I, University Medical Centre Schleswig-Holstein, Kiel University, Kiel

[21] European Huntington's Association, Moerbeke

[22] Medical Department, Takeda, Brussels

[23] Janssen LLC, GCSO Immunology, Horsham, PA

[24] Department of Neurology, Medical University Innsbruck, Innsbruck

来源：

Digital Biomarkers | 2024年 / 8卷 / 01期

关键词：

Activities of daily life; International Classification of Functioning; disability and health; Performance; Wearables;

D O I：

10.1159/000536568

中图分类号：

学科分类号：

摘要：

Background: Fatigue is a prominent symptom in many diseases and is strongly associated with impaired daily function. The measurement of daily function is currently almost always done with questionnaires, which are subjective and imprecise. With the recent advances of digital wearable technologies, novel approaches to evaluate daily function quantitatively and objectively in real-life conditions are increasingly possible. This also creates new possibilities to measure fatigue-related changes of daily function using such technologies. Summary: This review examines which digitally assessable parameters in immune-mediated inflammatory and neurodegenerative diseases may have the greatest potential to reflect fatiguerelated changes of daily function. Key Messages: Results of a standardized analysis of the literature reporting about perception-, capacity-, and performance-evaluating assessment tools indicate that changes of the following parameters: physical activity, independence of daily living, social participation, working life, mental status, cognitive and aerobic capacity, and supervised and unsupervised mobility performance have the highest potential to reflect fatigue-related changes of daily function. These parameters thus hold the greatest potential for quantitatively measuring fatigue in representative diseases in real-life conditions, e.g., with digital wearable technologies. Furthermore, to the best of our knowledge, this is a new approach to analysing evidence for the design of performance-based digital assessment protocols in human research, which may stimulate further systematic research in this area. © 2024 The Author(s). Published by S. Karger AG, Basel.

引用

页码：30 / 39

页数：9

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