In situ oxygen-generating bio-heterojunctions for enhanced anti-bacterial treatment of anaerobe-induced periodontitis

被引：0

作者：

Gong, Jing ^{[1
]}

Wang, Shunhua ^{[1
]}

Liu, Jie ^{[1
]}

Zhang, Yaowen ^{[1
]}

Li, Jiyao ^{[1
]}

Yang, Hao ^{[1
]}

Liang, Kunneng ^{[1
]}

Deng, Yi ^{[1
,2
,3
]}

机构：

[1] State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, School of Chemical Engineering, Sichuan University,

[2] State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu,610065, China

[3] Department of Mechanical Engineering, The University of Hong Kong, Hong Kong,999077, Hong Kong

来源：

Chemical Engineering Journal | 1600年 / 498卷

关键词：

Periodontitis; a chronic inflammatory condition associated with bacterial infection; is the leading cause of tooth loss in adults. Pathogenic bacteria that persist in deep periodontal pockets with hyperglycemic levels following traditional manual debridement can contribute to a persistent local inflammatory microenvironment; posing a significant challenge and highlighting the critical need for improved therapeutic approaches. In addition; the anaerobic environment during these treatments is beneficial to the colonization of anaerobes and may amplify inflammatory responses. Herein; we designed a glucose oxidase (GOx)-coating MXene-SnS2 bio-heterojunctions (MS@G bio-H[!text type='Js']Js[!/text]) for multi-modal and effective treatment of anti-bacteria and anti-inflammatory. Upon the hyperglycemic nidus in periodontal pockets; GOx catalyzes the conversion of glucose into hydrogen peroxide (H2O2). Subsequently; the breakdown of H2O2 into hydroxyl radicals through Sn2+/Sn4+-involved Fenton-like reactions enables in situ liberation of oxygen (O2); contributing to relieve local hypoxia. The proposed bio-H[!text type='Js']Js[!/text] presents a satisfactory bactericidal capability with anti-bacterial rates of more than 99 % upon near-infrared irradiation; in virtue of multi-modal therapies including photodynamic; photothermal and chemodynamic treatments. Furthermore; in vivo assays utilizing infectious rat models demonstrated that the proposed bio-H[!text type='Js']Js[!/text] exhibits high biocompatibility and capacity to alleviate hypoxia and reduce pathogenic virulence factors; potentially contributing to periodontal tissue regeneration. These findings suggest that the versatile bio-H[!text type='Js']Js[!/text] could be a promising therapeutic candidate for treating infectious periodontal diseases. © 2024 Elsevier B.V;

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摘要：

Journal article (JA)

引用

共 3 条

[1] In situ oxygen-generating bio-heterojunctions for enhanced anti-bacterial treatment of anaerobe-induced periodontitis
Gong, Jing
Wang, Shunhua
Liu, Jie
Zhang, Yaowen
Li, Jiyao
Yang, Hao
Liang, Kunneng
Deng, Yi
CHEMICAL ENGINEERING JOURNAL, 2024, 498
[2] Small Extracellular Vesicles Laden Oxygen-Releasing Thermosensitive Hydrogel for Enhanced Antibacterial Therapy against Anaerobe-Induced Periodontitis Alveolar Bone Defect
Ming, Leiguo
Qu, Yanling
Wang, Zhe
Dong, Lingjuan
Li, Yinghui
Liu, Fen
Wang, Qingxia
Zhang, Dan
Li, Zhifeng
Zhou, Zhifei
Shang, Fengqing
Xie, Xiaodong
ACS BIOMATERIALS SCIENCE & ENGINEERING, 2024, 10 (02): : 932 - 945
[3] Promoting the healing of infected diabetic wound by nanozyme-containing hydrogel with anti-bacterial inflammation suppressing, ROS-scavenging and oxygen-generating properties
Chen, Le-Ping
Wang, Xin-Yu
Ren, Ming-Jin
Wang, Yuan
Zhao, Jia-Meng
Qiang, Ti-Ti
Dong, Lin-Yi
Wang, Xian-Hua
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2024, 112 (08)

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