Enhancing the mechanical performance of 3D-printed self-hardening calcium phosphate bone scaffolds: PLGA-based strategies

被引:1
|
作者
Johansson, Linh [1 ,2 ,3 ,4 ,5 ]
Raymond, Yago [5 ]
Labay, Cedric [1 ,2 ,3 ,4 ]
Mateu-Sanz, Miguel [1 ,2 ,3 ,4 ]
Ginebra, Maria-Pau [1 ,2 ,3 ,6 ,7 ]
机构
[1] Univ Politecn Catalunya BarcelonaTech UPC, Dept Mat Sci & Engn CEM, Biomat Biomech & Tissue Engn Grp BBT, Ave Eduard Maristany 16, Barcelona 08019, Spain
[2] UPC, Barcelona Res Ctr Multiscale Sci & Engn, EEBE, Ave Eduard Maristany 10-14, Barcelona 08019, Spain
[3] UPC, Biomed Engn Res Ctr CREB, Ave Diagonal 647, Barcelona 08028, Spain
[4] Inst Recerca St Joan De Deu IRSJD, Dept Haematol & Oncol, Esplugues Del Llobregat 08950, Barcelona, Spain
[5] Mimetis Biomat SL, Carrer Cartagena 245 3E, Barcelona 08025, Spain
[6] Inst Bioengn Catalonia IBEC, Barcelona Inst Sci & Technol, Carrer Baldiri Reixac 10-12, Barcelona 08028, Spain
[7] Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed, Madrid, Spain
关键词
B; Composites; C. Mechanical properties; D; Apatite; E. Biomedical applications; COMPOSITE SCAFFOLD; ALKALINE-PHOSPHATASE; IN-VIVO; DIFFERENTIATION; REGENERATION; JOINT;
D O I
10.1016/j.ceramint.2024.08.473
中图分类号
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Over the last decade, 3D-printed porous calcium phosphates have emerged in the market for customized bone reconstruction. However, despite their excellent biological properties, the inherent brittleness is an obstacle that limits their clinical applications, as the scaffolds must withstand the surgical procedures and the mechanical stresses once implanted. Low-temperature self-hardening calcium phosphate inks offer unique possibilities to be reinforced with polymers, as they do not require high-temperature treatments. This study compares two routes for incorporating poly (lactic-co-glycolic acid) (PLGA) into 3D-printed calcium phosphate scaffolds: i) the use of a PLGA solution as a binder in an alpha-tricalcium phosphate self-hardening ink; ii) the infiltration of a PLGA solution into previously hardened 3D-printed calcium-deficient hydroxyapatite scaffolds. The influence of the added PLGA on the physical-chemical properties, mechanical performance and in vitro biological properties is assessed using a commercially available biomimetic calcium phosphate scaffold as a control. The addition of PLGA increases the plastic deformation capacity and the strength, both in compression and bending, and significantly improves the work of fracture of the scaffolds, up to an 8-fold in compression when PLGA is incorporated as a binder in the ink. Moreover, screwability tests demonstrate the enhanced fixability of the composite scaffolds in a knife-edge ridge indication with challenging fixation in the jaw. Importantly, the improvement of the mechanical properties by the addition of PLGA does not impair the good cytocompatibility of the material. Regarding the two routes studied, the PLGA incorporation in the ink is the best option in terms of overall improvement of the mechanical performance and osteogenic cell response.
引用
收藏
页码:46300 / 46317
页数:18
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