Au Nanorods Activate Zn2+/Ag+ Mediated Anti-inflammatory for Enhanced Methicillin-Resistant Wound Repair via Bionic Claw Microneedles

被引：8

作者：

Zheng, Wang ^{[1
]}

Shen, Hui ^{[1
]}

Cheng, Yuanfang ^{[2
]}

Liu, Litao ^{[1
]}

Sun, Jiangwei ^{[1
]}

Chu, Zhaoyou ^{[2
]}

Wang, Wanni ^{[1
,3
]}

Qian, Haisheng ^{[1
,3
,4
]}

机构：

[1] Anhui Med Univ, Anhui Prov Inst Translat Med, Sch Biomed Engn, Hefei 230032, Anhui, Peoples R China

[2] Anhui Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Hefei 230032, Anhui, Peoples R China

[3] Anhui Med Univ, Anhui Engn Res Ctr Med Micronano Devices, Hefei 230011, Anhui, Peoples R China

[4] Hefei Comprehens Natl Sci Ctr, Inst Hlth & Med, Hefei 230601, Anhui, Peoples R China

来源：

ACS MATERIALS LETTERS | 2024年 / 6卷 / 10期

基金：

中国国家自然科学基金;

关键词：

VEGF;

D O I：

10.1021/acsmaterialslett.4c01546

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Wound infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have attracted wide attention owing to acidic biofilms and the alkaline wound microenvironment, which result in hindering wound healing. In this work, we prepared an acid-base responsive bionic claw microneedle (MN) loaded with Au@ZnO/Ag (AZA) core-shell nanoparticles, which shows excellent photothermal transition and antibacterial activity. In the acidic medium of the biofilm, 97.98% of bacteria were successfully eradicated under mild thermal conditions (<= 40 degrees C). In the alkaline wound microenvironment, inflammatory cytokines were inhibited by Ag+. Vascular endothelial growth factor expression was promoted by trace Zn2+, and the wound healing rate increased by up to 24.02% compared to the control group. The bionic claw MN loaded with AZA effectively combines the benefits of low-temperature acidic sterilization and alkaline anti-inflammatory activity. The promotion of MRSA infected wound healing through the synergistic effect of released Zn2+/Ag+ and the mild thermal impact showcases new avenues for clinical treatment.

引用

页码：4791 / 4800

页数：10