Like versatile transformations of the Monkey King: A review of advancement in selective bio-oxidation of biomass polyols/aldehydes by Gluconobacter oxydans

Interest in converting biomass to produce renewable chemicals has increased in recent years. With this category, biomass polyols/aldehydes derived from lignocellulosic refining are cheap materials for preparing high valueadded chemicals. Therefore, for the bio-refining, the development of further high-value conversion of biomass polyols/aldehydes is not only conducive to improving the overall economic benefits of bio-refining, but also in line with the sustainable development. However, due to the characteristic of multiple reducing groups in biomass polyols/aldehydes, the selective catalytic oxidation of these groups has become the most challenging obstacle. Contrary to aerobic microorganisms that completely convert carbon sources into water and CO2, Gluconobacter oxydans shows a great development potential and application prospect with the advantages of incomplete oxidation with regio- and stereo-selectivity. This unique capability, along with its possession of a range of membrane-bound dehydrogenases that enable the production of many high-value-added products. G. oxydans as a privileged non-model microorganism has vigorously advanced the development of bioengineering. In this work, a comprehensive analysis was conducted on the recent advancements in selective catalysis of biomass polyols/aldehydes, providing theoretical guidance and technical support for the biopreparation of lignocellulosic acid and ketone platform compounds by G. oxydans.