A novel approach for prediction of intestinal absorption of drugs in humans based on hydrogen bond descriptors and structural similarity

被引：0
|
作者：
Raevsky, Oleg A. [1 ]
Schaper, Klaus-J. [2 ]
Artursson, Per [3 ]
McFarland, James W. [4 ]
机构：
[1] Department of Computer-Aided Molecular Design, Institute of Physiologically Active Compounds, 142432, Chernogolovka, Russia
[2] Research Center Borstel, Center for Medicine and Biosciences, Parkallee 1-40, D-23845, Borstel, Germany
[3] Department of Pharmaceutics, Uppsala University, P.O. Box 580, SE-751 23, Uppsala, Sweden
[4] Reckon.dat Consulting, 217 Blood Street, Lyme, CT 06371, United States
来源：
Quantitative Structure-Activity Relationships | 2001年 / 20卷 / 5-6期
关键词：
C values - Descriptors - Different mechanisms - Hydrogen bonding properties - Intestinal absorption - New approaches - QSAR - Sigmoid model - Similarity - Structural similarity;
D O I：
10.1002/1521-3838(200112)20:5/63.0.CO;2-6
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：402 / 413
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