Research Progress on the Toxicity of Acrylamide

被引:0
|
作者
Zhang L. [1 ]
Yang L. [1 ]
Wang P. [1 ]
Dong L. [1 ]
Hu X. [1 ]
Chen F. [1 ]
机构
[1] College of Food Science and Nutritional Engineering, China Agricultural University
[2] Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, Beijing
关键词
Acrylamide; Metabolism; Mitigation; Pathogenesis; Toxicity;
D O I
10.16429/j.1009-7848.2018.08.036
中图分类号
学科分类号
摘要
Acrylamide is an important chemical material, but also one of the byproducts of the Maillard reaction, widely found in hot processed foods. Its toxicity mainly includes neurotoxicity, reproductive toxicity, genotoxicity, immunotoxicity and carcinogenicity, among which neurotoxicity is confirmed in the human body. In this paper, the metabolism, toxicity, mechanism and toxicity mitigation of acrylamide were reviewed, and the future research direction of acrylamide was also discussed. © 2018, Editorial Office of Journal of CIFST. All right reserved.
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页码:274 / 283
页数:9
相关论文
共 47 条
  • [1] Zhang Y., Ren Y., Zhang Y., New research developments on acrylamide: analytical chemistry, formation mechanism, and mitigation recipes, Chemical Reviews, 41, 3, pp. 4375-4397, (2010)
  • [2] Zhang Y., Zhang Y., Formation and reduction of acrylamide in Maillard reaction: a review based on the current state of knowledge, Critical Reviews in Food Science and Nutrition, 47, 5, pp. 521-542, (2007)
  • [3] Molina-Garcia L., Santos C.S.P., Melo A., Et al., Acrylamide in chips and French fries: a novel and simple method using xanthydrol for its GC-MS determination, Food Analytical Methods, 8, 6, pp. 1436-1445, (2015)
  • [4] Exon J.H., A review of the toxicology of acrylamide, Journal of Toxicology and Environmental Health, Part B, 9, 5, pp. 397-412, (2006)
  • [5] Schettgen T., Kotting B., Hornig M., Et al., Trans-placental exposure of neonates to acrylamide-a pilot study, International Archives of Occupational and Environmental Health, 77, 3, pp. 213-216, (2004)
  • [6] Dearfield K.L., Abernathy C.O., Ottley M.S., Et al., Acrylamide: its metabolism, developmental and reproductive effects, genotoxicity, and carcinogenicity, Reviews in Genetic Toxicology, 195, 1, pp. 45-77, (1988)
  • [7] Boettcher M.I., Bolt H.M., Drexler H., Et al., Excretion of mercapturic acids of acrylamide and glycidamide in human urine after single oral administration of deuterium-labelled acrylamide, Archives of Toxicology, 80, 2, pp. 55-61, (2006)
  • [8] Calleman C.J., The metabolism and pharmacokinetics of acrylamide: implications for mechanisms of toxicity and human risk estimation, Drug Metabolism Reviews, 28, 4, pp. 527-590, (1996)
  • [9] Chevolleau S., Jacques C., Canlet C., Et al., Analysis of hemoglobin adducts of acrylamide and glycidamide by liquid chromatography-electrospray ionization tandem mass spectrometry, as exposure biomarkers in French population, Journal of Chromatography A, 1167, 2, pp. 125-134, (2007)
  • [10] Gao J., Zhao Y., Zhu F., Et al., Dietary exposure of acrylamide from the fifth Chinese Total Diet Study, Food and Chemical Toxicology, 87, pp. 97-102, (2016)