Effects of Green Tea Extract on Aluminum Induced Oxidative Stress in Rat Brain

被引：0
|
作者：
Hao C. [1 ]
Tian W. [1 ]
Jiang W. [1 ]
机构：
[1] College of Food Science and Nutritional Engineering, China Agricultural University, Beijing
来源：
Journal of Chinese Institute of Food Science and Technology | 2017年 / 17卷 / 05期
关键词：
Aluminum; Antioxidant; Green tea extract; Lipid peroxidation; Oxidate stress;
D O I：
10.16429/j.1009-7848.2017.05.001
中图分类号：
学科分类号：
摘要：
Objective: To assess the effects of GTE on oxidative stress in rat brain induced by aluminum. Methods: Six SD rats per group were assigned to one of four treatment groups: control, AlCl3 (111.9 mg/kg BW), AlCl3 plus GTE, GTE (1.5% tea infusions). GTE was given orally to the rats with drinking water and Al was given orally to the rats for 4 weeks. Al concentration in the digested tissues of brain and serum were detected using ICP-MS. Activity of GSH-Px, GST, GR in the serum, activity of SOD, CAT, GSH-Px, GST, GR and content of GSH, MDA in brain were quantitatively measured. Rusults: Serum and brain Al concentration in GTE group were significantly decreased comparing with AlCl3-treated rats (P<0.01, P<0.01), the contents of MDA in brain markedly decreased, the activity of antioxidant enzymes in serum and brain of were significantly increased. Cluclusion: This study confirms that GTE has effects of antioxidative and antihyperlipidemia, and contributes to reduce the risk of Oxidate stress caused by aluminum. © 2017, Editorial Office of Journal of CIFST. All right reserved.
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页码：1 / 9
页数：8
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