Kinetics of reaction extraction separation of 2-phenylbutyric acid enantiomers

被引：0
|
作者：
Jiang P. [1 ]
Zhang P. [2 ]
Zeng L. [2 ]
Xu W. [2 ]
Tang K. [2 ]
机构：
[1] College of Chemical Engineering, Xiangtan University, Xiangtan, 411105, Hunan
[2] Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, 414006, Hunan
来源：
Tang, Kewen (tangkewen@sina.com) | 2017年 / Materials China卷 / 68期
关键词：
2-phenylbutyric acid; Chemical reactive; Extraction; Kinetics;
D O I：
10.11949/j.issn.0438-1157.20161190
中图分类号：
学科分类号：
摘要：
Kinetics research on the reactive extraction of 2-phenylbutyric acid enantiomers using hydroxyethyl-β-cyclodextrin (HE-β-CD) as extractant was performed in a Lewis cell. A homogeneous reaction model and a two-film theory were employed to describe the mass transfer mechanism of the reactive extraction process. The process parameters affecting the initial extraction rate, including agitation speed, interfacial area, pH value of aqueous phase, initial concentration of 2-phenylbutyric acid (2-PBA) enantiomers and initial concentration of extractant, were separately studied. The results showed that the reaction between hydroxyethyl-β-cyclodextrin and 2-phenylbutyric acid was a fast reaction. It was found that the reaction was first order in 2-phenylbutyric acid and second order in hydroxyethyl-β-cyclodextrin. The forward rate constants for the extraction of (+)-2-phenylbutyric acid and (-)-2-phenylbutyric acid were 2.829×10-4 and 1.803×10-4 m6·mol-2·s-1, respectively. The results were useful for the design and operation of reactive extraction process in large-scale production, and provide scientific basis for equipment design and process intensification. © All Right Reserved.
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页码：163 / 169
页数：6
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