Effect of Celecoxib on Electrophysiological Property of Cardiac Sodium Channel Nav1.5

被引：0
|
作者：
Sun J.-F. [1 ]
Xu Y.-J. [2 ]
Wang Z.-Y. [1 ]
机构：
[1] School of Life and Health Sciences, Northeastern University, Shenyang
[2] School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang
来源：
Dongbei Daxue Xuebao/Journal of Northeastern University | 2019年 / 40卷 / 03期
关键词：
Cardiovascular risk; Celecoxib; Electrophysiological property; Na[!sub]v[!/sub]1.5; Whole cell patch clamp;
D O I：
10.12068/j.issn.1005-3026.2019.03.028
中图分类号：
学科分类号：
摘要：
The effect of celecoxib on electrophysiological property of Nav1.5 was studied,which was associated with cardiac toxicity. The effects of celecoxib on the electrophysiological properties of Nav 1.5, including peak current, voltage-dependent activation, voltage-dependent inactivation and recovery kinetics, were investigated by whole cell patch clamp technique. The results showed that celecoxib inhibited the peak currents of Nav1.5 in a concentration-dependent manner with a calculated IC50 value of 1.54×10-8mol/L. Moreover, celecoxib promoted the activation and inactivation phase of Nav1.5, making it somewhat difficult to recover from the inactivation to the resting state. The prominent inhibition of celecoxib on Nav1.5 indicated that there might be a close relationship between potential cardiovascular risks and Nav1.5. © 2019, Editorial Department of Journal of Northeastern University. All right reserved.
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页码：452 / 456
页数：4
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