Reservoirs are important for regulating water and sediment and optimizing water resource allocation in the Yellow River Basin(YRB). Initially, reservoir regulation in the YRB was aimed at flood control and sedimentation reduction. Under the new situation, the YRB faces constantly changing conditions for incoming water and sediment, constraints from the reservoir to the river boundary, regional socio-economic development, and ecological environment needs. The YRB urgently needs to highlight the multi - objective scheduling of reservoirs from a systemic perspective. Based on the theory and methods of systems science, this article uses techniques such as data analysis, data mining, correlation identification, and regression analysis to screen the characterization indicators of flood and sediment transport, ecological environment, and socio-economic subsystems in the YRB system. It elucidates the evolution process of multi-dimensional constraint factors in different sections of the Yellow River's upper, middle, and lower reaches. It reveals the interaction relationship between the main constraint factors in the regulation system of the Yellow River mainstream. A multi-objective collaborative constraint factor threshold for the operation of reservoirs in the mainstream of the Yellow River has been proposed, providing support for the multi-objective dynamic process of pools in the YRB. © 2024 International Research and Training Center on Erosion and Sedimentation and China Water and Power Press. All rights reserved.