Poly-3-hydroxyalkanoates-co-polyethylene glycol methacrylate copolymers for pH responsive and shape memory hydrogel

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[1] Gumel, Ahmad Mohammed
[2] 1,Annuar, Mohamad Suffian Mohamad
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Gumel, A.M. (gumel@um.edu.my) | 1600年
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Multifunctional hydrogels combining the capabilities of cellular pH responsiveness and shape memory; are highly promising for the realization of smart membrane filters; controlled drug released devices; and functional tissue-engineering scaffolds. In this study; lipase was used to catalyze the synthesis of medium-chain-length poly-3-hydroxyalkanoates-co-polyethylene glycol methacrylate (PHA-PEGMA) macromer; which was used to prepare pH-responsive and shape memory hydrogel via free radical polymerization. Increasing the PEGMA fraction from 10 to 50% (mass) resulted in increased thermal degradation temperature (Td) from 430 to 470°C. Highest lower critical solution temperature of 37°C was obtained in hydrogel with 50% PEGMA fraction. The change in PEGMA fraction was also found to highly influence the hydrogel's hydration rate (r) from 2.8 × 10-5 to 7.6 × 10-5 mL·s-1. The hydrogel's equilibrium weight swelling ratio (qe); protein release and its diffusion coefficient (Dm) were all found to be pH dependent. Increasing the phosphate buffer pH from 2.4 to 13 resulted in increased qe from 2 to 16 corresponding to the enlarging of network pore size (ξ) from 150 to 586 nm. Different types of crosslinker for the hydrogel influenced its flexibility and ductility. © 2014 Wiley Periodicals; Inc;
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