Preparation of Poly(lactic-co-glycolic acid) Drug-Loaded Porous Solid Microspheres by Shear of Coagulation Bath Method

被引：0
|
作者：
Du L. [1 ]
Yang Q. [2 ]
Yang X. [1 ]
Li W. [1 ]
Yu B. [2 ]
Tu M. [1 ]
机构：
[1] College of Science and Engineering, Jinan University, Guangzhou
[2] Nanfang Hospital, Southern Medical University, Guangzhou
来源：
Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering | 2017年 / 33卷 / 07期
关键词：
Coagulating bath; Composite structure; Poly(lactic-co-glycolic acid); Porous microspheres; Release property;
D O I：
10.16865/j.cnki.1000-7555.2017.07.023
中图分类号：
学科分类号：
摘要：
This reserch presented a study on preparation of poly(lactic-co-glycolic acid) (PLGA) based composite structure microspheres loaded with vancomycin hydrochloride by a novel coagulating bath and characterizations of their surface morphology, size, encapsulation efficiency, drug-loading rate, in vitro drug release properties and relative influencing factors. The results indicate that the drug-loaded microspheres, with diameters in the range of 15~29 μm, exhibit composite construction with solid interior and porous surface. Their encapsulation efficiency and drug-loading rate could be regulated within the range of 15%~74% and 1.5%~9.3%, respectively. The preparation conditions for microspheres have significant impacts on their structure and surface morphology, encapsulation efficiency, drug-loading rate and release properties. It is demonstrated that the sudden release of the drug can be improved by controlling the diameter of drug-loaded microspheres. © 2017, Editorial Board of Polymer Materials Science & Engineering. All right reserved.
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页码：131 / 137
页数：6
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