Micronization of poly(lactic acid) by supercritical fluid assisted atomization with intensifying two-phase mixing

被引：0
|
作者：
Wang Q. [1 ]
Cai M.-Q. [1 ]
Guan Y.-X. [1 ]
Yao S.-J. [1 ]
Zhu Z.-Q. [1 ]
机构：
[1] Department of Chemical and Biochemical Engineering, Zhejiang University
来源：
Zhejiang Daxue Xuebao (Gongxue Ban)/Journal of Zhejiang University (Engineering Science) | 2010年 / 44卷 / 12期
关键词：
Hydrodynamic cavitation; Mixer; Poly(lactic acid); Supercritical fluid assisted atomization; Two-phase mass transfer; Ultrafine microparticle;
D O I：
10.3785/j.issn.1008-973X.2010.12.025
中图分类号：
学科分类号：
摘要：
To resolve the problem of wide particle size distribution of the commercial poly(lactic acid) (PLA) microspheres for aerosol delivery, a novel technique named supercritical fluid assisted atomization introduced by hydrodynamic cavitation mixer (SAA-HCM) was developed to prepare the PLA microparticles. The primary advantage of SAA-HCM is the intensifying mixing between supercritical carbon dioxide, and liquid feedstock by introducing a hydrodynamic cavitation mixer. The effects of different process parameters such as mixer pressure, mixer temperature, precipitator temperature, mass flow ratio between carbon dioxide and liquid solution, and solute concentration were investigated to evaluate their influences on the morphology and size distribution of precipitated particles. Microparticles of PLA was successfully prepared with a narrow particle size distribution (1-3 μm) and well-defined spherical shape at optimized conditions. Compared with the untreated PLA, X-ray diffraction (XRD) and differential scanning calorimetry (DSC) results suggested that there were no significant changes in crystalline type and heat properties, but prominent decrease in the crystalline of the resulting PLA products was observed. Considering the phase behavior, the influencing mechanism of the process parameters on the microparticle morphology was interpreted briefly. The results indicated that in contrast with SAA, the intensification of the mass transfer between the two phases in the mixer was verified and very sharp PSD can be obtained, that lies in the particle size range of aerosolizable drugs.
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页码：2383 / 2390
页数：7
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