Polyphenols from Lonicera caerulea L. Berry Inhibit LPS-Induced Inflammation through Dual Modulation of Inflammatory and Antioxidant Mediators

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作者
机构
[1] Wu, Shusong
[2] Yano, Satoshi
[3] Chen, Jihua
[4] Hisanaga, Ayami
[5] 2,Sakao, Kozue
[6] He, Xi
[7] He, Jianhua
[8] 1,2,Hou, De-Xing
来源
Hou, De-Xing (hou@chem.agri.kagoshima-u.ac.jp) | 1600年 / American Chemical Society卷 / 65期
基金
日本学术振兴会;
关键词
Fruits - Pathology - Flavonoids - Superoxide dismutase - Body fluids - Metabolites - Metadata - Cell signaling - Macrophages - Manganese compounds;
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摘要
Lonicera caerulea L. berry polyphenols (LCBP) are considered as major components for bioactivity. This study aimed to clarify the molecular mechanisms by monitoring inflammatory and antioxidant mediator actions in lipopolysaccharide (LPS)-induced mouse paw edema and macrophage cell model. LCBP significantly attenuated LPS-induced paw edema (3.0 ± 0.1 to 2.8 ± 0.1 mm, P © 2017 American Chemical Society.
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