Chestnut Shells Pigment Ameliorated Lipid Metabolism Disorder in Obese Mice through AMPK Signaling Pathway

被引：0

作者：

Zhang X. ^{[1
,2
]}

Mei X. ^{[1
,2
]}

机构：

[1] College of Food Science and Nutrition Engineering, China Agricultural University, Beijing

[2] Key Laboratory of Safety Assessment of Oenetically Podified Rrganism (Food Safety), Pinistry of Agriculture and Rural Affairs, Beijing

来源：

Journal of Chinese Institute of Food Science and Technology | 2023年 / 23卷 / 07期

关键词：

adenosine monophosphate activated protein kinase; chestnut shells pigment; high fat diet; lipid metabolism; obesity;

D O I：

10.16429/j.1009-7848.2023.07.019

中图分类号：

学科分类号：

摘要：

Objective: To investigate the improvement effect of chestnut shells pigment (CSP) on lipid metabolism disor- der in obese mice and its molecular mechanism. Methods: Male C57BL/6J mice were divided into normal diet group (N), high fat diet group (HFD), high fat diet E20 mg/kg CSP group (HFD-L), high fat diet E50 mg/kg CSP group (HFD-H), high fat diet E20 mg/kg catechin group (HFD-C). The body weight and food intake of mice were measured every week. After 14 weeks, the weight of liver and epididymis fat of mice and lipid levels of serum were detected. The morphology of fat and liver was analyzed and the expression of key proteins of fat metabolism in liver was detected. Results: Compared with HFD group, the gain of body mass in HFD-L and HFD-H groups decreased by 28.67U and 39.16U, respectively. Fat mass of epididymis decreased by 23.63U and 42.80U, respectively. CSP can reduced food intake and accumulation of liver fat, reduced serum TG, TC, LDL-C, ALT and AST levels, increased HDL-C. The expression levels of p-AMPK/AMPK, p-ACC/ACC and PPAR! in liver tissue were significantly increased, however, the expression levels of SREBP-1C and HMGCR were significantly decreased, which were better than those of pure catechin. Conclusion: CSP can improve lipid metabolism in obese mice, which is related to the activation of AMPK signaling pathway. © 2023 Chinese Institute of Food Science and Technology. All rights reserved.

引用

页码：177 / 186

页数：9

共 33 条

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