Unlocking innovative hydrogel treatments

被引：0

作者：

Laverty, Garry ^{[1
]}

An, Yuming ^{[2
]}

Pentlavalli, Sreekanth ^{[1
]}

机构：

[1] School of Pharmacy, Queen’s University, Belfast, United Kingdom

[2] Queen's University, Belfast, United Kingdom

来源：

European Pharmaceutical Review | 2024年 / 29卷 / 01期

关键词：

The research; which began six years ago with the support of the Wellcome Trust and subsequently funded by several sources including the Engineering & Physical Sciences Research Council (EPSRC); involves linking zidovudine to a short; specially developed peptide. This peptide acts as a carrier for the drug; which can be kept stable as a powder formulation to avoid aggregation during storage u2013 a process in which small molecules within suspension formulation come together to form larger aggregates; which can affect the efficacy and safety of the drug. This is a particular challenge when transporting medicines across several climatic zones and in low-to middle-income countries where cold storage and distribution are more difficult.5 The peptide; initially soluble upon injection into the body; also acts as a slow-release mechanism by transforming into a gel in the presence of certain enzymes to slow down depletion of the drug; allowing for systematic drug delivery throughout the body to prevent HIV replication. This innovative approach allows the delivery of a combination of drugs over several months; liberating patients from the daily medication routine. Furthermore; long-acting treatment also ensures precise dosing; effective viral suppression; and a reduced risk of antimicrobial resistance; marking a significant stride in HIV treatment;

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摘要：

(Edited Abstract)

引用

页码：37 / 43

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