In this paper, thermal radiation and chemical reaction impacts on MHD peristaltic motion of the Eyring-Powell fluid are analyzed through a porous medium in a channel with compliant walls under slip conditions for velocity, temperature, and concentration. Assumptions of a long wavelength and low Reynolds number are considered. The modeled equations are computed by using the perturbation method. The resulting non-linear system is solved for the stream function, velocity, temperature, concentration, skin-friction coefficient, heat transfer coefficient, and mass transfer coefficient. The flow quantities are examined for various parameters. Temperature is depressed with an enhanced radiation parameter, while the opposite effect is observed for the concentration. The fluid concentration is enhanced and depressed with generative and destructive chemical reaction, respectively. The size of the trapped bolus reduces as the Powel-Eyring parameter increases while it increases as another Powell fluid parameter rises. Furthermore, the size of the trapped bolus grows when Darcy number increases. © 2019, Shahid Rajaee Teacher Tarining University (SRTTU). All rights reserved.