Research Progress on Antitumor Activity and Mechanism of Ginsenosides

被引：0
|
作者：
Wang Y. [1 ,2 ]
Ai Z. [1 ,2 ]
Zhang J. [1 ,2 ]
Hu Y. [1 ,2 ]
Liu S. [1 ,2 ]
Liu Y. [1 ,2 ]
Wang Y. [1 ,2 ]
Nan B. [1 ,2 ]
机构：
[1] College of Food Science and Engineering, Jilin Agricultural University, Changchun
[2] Jilin Province Innovation Center for Food Biological Manufacture, Jilin Agricultural University, Changchun
来源：
Science and Technology of Food Industry | 2023年 / 44卷 / 01期
关键词：
antitumor; ginseng; ginsenosides; mechanism;
D O I：
10.13386/j.issn1002-0306.2022030278
中图分类号：
学科分类号：
摘要：
Ginseng is an important food and medicine homologous plant, which has various physiological functions of antitumor, antiinflammatory, antifatigue and improving immunity. Ginsenosides are the most important active components in ginseng, in vivo and in vitro experiments have confirmed that ginsenosides have significant antitumor activity, among which ginsenoside Rg3 has been used as a monomer drug for adjuvant therapy of tumor patients. Studies have shown that the anti-tumor activity of ginsenosides is achieved through different pathways, including inhibiting tumor cell proliferation, inducing tumor cell apoptosis, inhibiting tumor cell invasion and metastasis, blocking tumor angiogenesis, enhancing organism immune system, and resisting oxidation stress, and synergizing with chemotherapy drugs. This article reviews the antitumor action pathways of ginsenosides, provides a theoretical basis for the development of ginseng antitumor functional foods. © 2023, Editorial Department of Science and Technology of Food Science. All rights reserved.
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页码：485 / 491
页数：6
相关论文
共 70 条
  • [1] BAEG I H, SO S H., The world ginseng market and the ginseng (Korea)[J], Journal of Ginseng Research, 37, 1, (2013)
  • [2] RIAZ M, RAHMAN N U, ZIA-UL-HAQ M, Et al., Ginseng: A dietary supplement as immune-modulator in various diseases[J], Trends in Food Science & Technology, 83, pp. 12-30, (2019)
  • [3] FAN J, WANG Y, YOU Y, Et al., Fermented ginseng improved alcohol liver injury in association with changes in the gut mi-crobiota of mice[J], Food & Function, 10, 9, (2019)
  • [4] YING Y, ZHANG Y L, MA C J, Et al., Neuroprotective effects of ginsenoside Rg1 against hyperphosphorylated tau-induced diabet-ic retinal neurodegeneration via activation of IRS-1/Akt/GSK3beta signaling[J], Journal of Agricultural and Food Chemistry, 67, 30, pp. 8348-8360, (2019)
  • [5] CHEN H, YANG H, DENG J, Et al., Ginsenoside Rk3 amelio-rates obesity-induced colitis by regulating of intestinal flora and the TLR4/NF-kappaB signaling pathway in C57BL/6 mice[J], Journal of Agricultural and Food Chemistry, 69, 10, pp. 3082-3093, (2021)
  • [6] LIU Y, FAN D., Ginsenoside Rg5 induces G2/M phase arrest, apoptosis and autophagy via regulating ROS-mediated MAPK pathways against human gastric cancer[J], Biochemical Pharmacology, 168, pp. 285-304, (2019)
  • [7] SIEGEL R L, MILLER K D, JEMAL A., Cancer statistics, 2020 [J], CA: A Cancer Journal for Clinicians, 70, 1, pp. 7-30, (2020)
  • [8] BRAY F, FERLAY J, SOERJOMATARAM I, Et al., Global cancer statistics 2018: GLOBOCAN estimates of incidence and mor-tality worldwide for 36 cancers in 185 countries[J], CA:A Cancer Journal for Clinicians, 68, 6, pp. 394-424, (2018)
  • [9] RADY I, MOHAMED H, RADY M, Et al., Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea[J], Egyptian Journal of Basic and Applied Sciences, 5, 1, pp. 1-23, (2019)
  • [10] CUI H, BASHAR M A E, RADY I, Et al., Antiproliferative activity, proapoptotic effect, and cell cycle arrest in human cancer cells of some marine natural product extract[J], Oxidative Medicine and Cellular Longevity, 2020, (2020)
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