Preparation and characterization of silk fibroin hydrogel in acid-alcohol system

被引：0
|
作者：
Liu H. [1 ]
Lu M. [1 ]
Huang X. [1 ,2 ]
Wang N. [1 ,2 ]
Wang X. [1 ,2 ]
Ning X. [2 ,3 ]
Ming J. [1 ,2 ,3 ]
机构：
[1] College of Textiles & Clothing, Qingdao University, Qingdao
[2] Industrial Research Institute of Nonwovens & Technical Textiles, Qingdao University, Qingdao
[3] Shandong Special Nonwoven Materials Engineering Research Center, Qingdao
来源：
Fangzhi Xuebao/Journal of Textile Research | 2021年 / 42卷 / 08期
关键词：
Acid-alcohol system; Compression property; Crystallization structure; Hydrogel; Medical material; Silk fibroin;
D O I：
10.13475/j.fzxb.20200901308
中图分类号：
学科分类号：
摘要：
In order to achieve the controllable morphology of silk fibroin hydrogel and to improve the gelling speed and compression properties, a simple fabrication method for silk fibroin hydrogel in acid-alcohol system was developed. This paper reports the effect of alcohol with different mass ratio on the morphology, aggregation structure, thermal property and compressive property of hydrogel at the same acidic condition. The research explored the forming conditions for silk fibroin hydrogels, and the differences in structure and properties of hydrogel. The results show that the structure and properties of hydrogels are improved with increased use of alcohol, which also benefited the gelation time reduction from 12-14 h to 1 h. In relation to this, the morphology of hydrogel gradually changes from pore to fibrous state. Moreover, the crystallization structure of silk fibroin in hydrogels was found to be mainly β-sheet. When the mass ratio of alcohol was set to 5.0%, the fiber diameter reached (1.09±0.5) μm. The hydrogels demonstrated a compressive strength of (75.16±3.79) kPa at 60% strain in dry state, and the compression recovery rate reached 63% in wet state. © 2021, Periodical Agency of Journal of Textile Research. All right reserved.
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页码：41 / 48
页数：7
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共 38 条
  • [1] ZHANG Yemin, Preparation and characterization of gelatin-chitosan IPN biohydrogels by bienzymatic crosslinking approach, pp. 1-2, (2015)
  • [2] JANANI Guru, KUMAR Manishekhar, CHOUHAN Dimple, Et al., Insight into silk based biomaterials from physicochemical attributes to recent biomedical applications, ACS Applied Bio Materials, 2, pp. 5460-5491, (2019)
  • [3] LI Jiale, TAN Yunfei, TAN Xulin, Et al., Research progress on the applications of silk fibroin hydrogel in the tissue engineering, Materials Reports, 32, S2, pp. 176-182, (2018)
  • [4] ZHOU Qian, YUAN Jiugang, LI Lan, Et al., Phosphorylation of silk fibroin and preparation of biomimetic mineralization membrane thereof, Journal of Textile Research, 39, 11, pp. 8-13, (2018)
  • [5] GRIGORYAN B, PAULSEN S J, CORBETT D C, Et al., Multivascular networks and functional intravascular topologies within biocompatible hydrogels, Science, 364, pp. 458-464, (2019)
  • [6] HAN Yanxin, YANG Wenbo, CUI Wenguo, Et al., Development of functional hydrogels for heart failure, Journal of Materials Chemistry B, 7, (2019)
  • [7] LIU Bin, SONG Yuwei, JIN Li, Et al., Silk structure and degradation, Colloids and Surfaces B: Biointerfaces, 131, pp. 122-128, (2015)
  • [8] WU Jianbing, ZHANG Lixiang, TANG Qilin, Research progress of silk fibroin nano-microspheres for drug-controlled release, Journal of Silk, 57, 5, pp. 6-10, (2020)
  • [9] WU Xilong, Preparation and characterization of injectable in-situ regenerated silk hydrogels, pp. 5-8, (2012)
  • [10] NAGAEKAR Shailesh, Avinash PATIL, LELE Ashish, Et al., Some mechanistic insights into the gelation of regenerated silk fibroin sol [J], Industrial & Engineering Chemistry Research, 48, 17, pp. 8014-8023, (2009)
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