A biokinetic model for trivalent or hexavalent chromium in adult humans

被引:7
|
作者
Hiller M.M. [1 ]
Leggett R.W. [1 ]
机构
[1] Center for Radiation Protection Knowledge, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, 37831, TN
关键词
biokinetic model; chromium; hexavalent chromium; metabolism; trivalent chromium;
D O I
10.1088/1361-6498/ab4286
中图分类号
X9 [安全科学];
学科分类号
0837 ;
摘要
Chromium exists in several oxidation states, with the trivalent state (Cr(III)) being the dominant naturally occurring form. Chromium in other oxidation states tends to be converted to the trivalent oxide in the natural environment and in biological systems. Chromium(III) has been shown to be an essential nutrient for humans and several non-human species. Chromium(VI), the second most stable form of chromium, is an important environmental contaminant that is mostly of industrial origin and is associated with lung cancer and nose tumours in chromium workers. This paper proposes a biokinetic model for chromium that addresses the distinctive behaviours of Cr(III) and Cr(VI) following uptake to blood of an adult human. The model is based on biokinetic data derived from relatively short-term studies involving administration of chromium tracers to adult human subjects or laboratory animals, supplemented with data on the long-term distribution of chromium in adult humans as estimated from autopsy measurements. The model is part of a comprehensive update of biokinetic models of the International Commission on Radiological Protection, used to project or evaluate radiation doses from occupational intake of radionuclides. © 2019 Society for Radiological Protection. Published on behalf of SRP by IOP Publishing Limited. All rights reserved..
引用
收藏
页码:19 / 39
页数:20
相关论文
共 50 条
  • [1] Chromium: Trivalent or hexavalent?
    Hauser, Herbert
    Galvanotechnik, 2022, 113 (06): : 781 - 782
  • [2] A biokinetic model for systemic technetium in adult humans
    Leggett, R.
    Giussani, A.
    JOURNAL OF RADIOLOGICAL PROTECTION, 2015, 35 (02) : 297 - 315
  • [3] Spectroscopic measurement of trivalent and hexavalent chromium
    Vaskova, Hana
    Kolomaznik, Karel
    PROCEEDINGS OF THE 2016 17TH INTERNATIONAL CARPATHIAN CONTROL CONFERENCE (ICCC), 2016, : 775 - 778
  • [4] Urinary chromium concentrations in humans following ingestion of safe doses of hexavalent and trivalent chromium: Implications for biomonitoring
    Finley, BL
    Scott, PK
    Norton, RL
    Gargas, ML
    Paustenbach, DJ
    JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1996, 48 (05): : 479 - 499
  • [5] Reduction of hexavalent chromium to trivalent chromium by Phanerochaete chrysosporium
    Pal, N
    IN SITU AND ON-SITE BIOREMEDIATION, VOL 2, 1997, 4(2) (02): : 511 - 517
  • [6] COMPARATIVE TOXICITY OF TRIVALENT AND HEXAVALENT CHROMIUM TO FUNGI
    BABICH, H
    SCHIFFENBAUER, M
    STOTZKY, G
    BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1982, 28 (04) : 452 - 459
  • [7] EFFECTS OF HEXAVALENT AND TRIVALENT CHROMIUM COMPOUNDS ON SKIN
    SAMITZ, MH
    GROSS, S
    ARCHIVES OF DERMATOLOGY, 1961, 84 (03) : 404 - &
  • [8] Trivalent and hexavalent chromium issues in medical implants
    Eiselstein, L. E.
    Proctor, D. M.
    Flowers, T. C.
    THERMEC 2006, PTS 1-5, 2007, 539-543 : 698 - +
  • [9] Removal of trivalent and hexavalent chromium by seaweed biosorbent
    Kratochvil, David
    Pimentel, Patricia
    Volesky, Bohumil
    Environmental Science and Technology, 1998, 32 (18): : 2693 - 2698
  • [10] Removal of trivalent and hexavalent chromium by seaweed biosorbent
    Kratochvil, D
    Pimentel, P
    Volesky, B
    ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1998, 32 (18) : 2693 - 2698