Effects of Camel Milk on Glucolipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease

被引：0
|
作者：
Hao S. [1 ]
Li Y. [1 ]
Wu X. [1 ]
Na Q. [1 ]
Ming L. [1 ]
Zhang X. [2 ]
Ji R. [1 ]
机构：
[1] Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot
[2] Center of Alxa Right Banner Agricultural Technology Promotion, Alxa
来源：
Science and Technology of Food Industry | 2023年 / 44卷 / 06期
关键词：
C57BL/6J mice; camel milk; glucose and lipid metabolism; high fat; high sugar and high cholesterol diet; non-alcoholic fatty liver disease;
D O I：
10.13386/j.issn1002-0306.2022060164
中图分类号：
学科分类号：
摘要：
Objective: This study was designed to explore the effect of camel milk on glucose and lipid metabolism metabolism in mice with nonalcoholic fatty liver disease induced by high fat, high sugar and high cholesterol diet. Methods: 50 C57BL6/J male mice were randomly divided into control group (NC), model group (Mod), control camel milk group (NCM, 3g·kg−1 bw), camel milk group (CaM, 3 g·kg−1 bw) and silymarin group (PC, 200 mg·kg−1 bw). The model of nonalcoholic fatty liver was established for 12 weeks. The mice in the camel milk group and the silymarin group were gavaged with the corresponding doses of camel milk and silymarin at a fixed time every day, respectively. Body weight, fasting blood glucose, serum biochemical, insulin resistance and insulin sensitivity, oral glucose tolerance and insulin tolerance were measured to investigate the effect of camel milk on glucolipid metabolism in mice with non-alcoholic fatty liver disease induced by high fat, high sugar, and high cholesterol diet. Results: Camel milk significantly inhibited the increase of body weight and blood sugar of NAFLD mice and notably reduced the levels of total triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), tumor necrosis factor (TNF-α), leptin (LEP) and insulin (INS) (P<0.05). While the adiponectin (ADPN) levels in mice serum was increased (P<0.05). In the camel milk group, the glucose tolerance were significantly increased, insulin resistance was reduced, and insulin sensitivity was significantly improved (P<0.05), indicating glucose and lipid metabolism was enhanced. Conclusion: Camel milk had a modulatory role in glucose and lipid metabolism in NAFLD mice induced by high-fat, high-sugar and high-cholesterol diet, which would increase the glucose and lipid metabolism by alleviating insulin resistance and promoting serum lipid transport. © 2023, Editorial Department of Science and Technology of Food Science. All rights reserved.
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页码：376 / 383
页数：7
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