Review on the Influence of Surface Micro-nano Structure and Bioactive Ions of Biomedical Titanium Implants on Biocompatibility

被引：0
|
作者：
Ji Z. [1 ,2 ]
Wan Y. [1 ,2 ]
Zhao Z. [1 ,2 ]
Wang H. [3 ,4 ]
Fan S. [1 ,2 ]
Liu Z. [1 ,2 ]
机构：
[1] Key Laboratory of High-efficiency and Clean Mechanical Manufacture of Ministry of Education, Shandong University, Jinan
[2] School of Mechanical Engineering, Shandong University, Jinan
[3] Emergency Department, Qilu Hospital of Shandong University, Jinan
[4] Shandong University Acute and Critical Care Clinical Medicine Research Center, Qilu Hospital of Shandong University, Jinan
来源：
Zhongguo Biaomian Gongcheng/China Surface Engineering | 2022年 / 35卷 / 04期
基金：
中国国家自然科学基金;
关键词：
bioactive ions; biocompatibility; micro-nano structure; surface modification; synergistic effect; titanium implant;
D O I：
10.11933/j.issn.1007-9289.20211123002
中图分类号：
学科分类号：
摘要：
As an important factor affecting the biocompatibility of implant, the surface micromorphology and chemical composition of the biomedical titanium implant determine the stability and service life of the implant, and have been widely studied. It is extremely important to systematically review the research status of surface modification of titanium implants. This paper reviews the research status of the construction of micro-nano structure on the surface of titanium implants and the addition of typical bioactive ions, and the synergistic effects of the combination of the two on promoting cell adhesion, proliferation, differentiation and promoting osteogenesis in animals. Besides, this paper briefly describes the internal regulation mechanism of micro-nano structure on cell behavior. The review indicates that the micro-nano structure and bioactive ions on the surface of titanium implants have a positive effect on the behavior of cells, and implants with both can better promote cell adhesion, proliferation and differentiation. It is more conducive to the osseointegration of the implant and the surrounding tissue after in vivo. Finally, according to the problems of poor antibacterial performance and unclear effect on cells in the current research on surface modification of biomedical titanium implants, the research trend in the field of surface modification is proposed. The research status and future development direction of micro-nano structure construction and bioactive ions addition in the field of titanium implant surface modification are proposed, This paper fills the gap in the surface modification of titanium implant and provides a reference for the future development of titanium implant surface modification. © 2022 Chinese Mechanical Engineering Society. All rights reserved.
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页码：84 / 101
页数：17
相关论文
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