Prenatal dexamethasone exposure induced pancreatic β-cell dysfunction and glucose intolerance of male offspring rats: Role of the epigenetic repression of ACE2

被引:0
|
作者
Dai, Yongguo [1 ]
Kou, Hao [2 ,3 ]
Gui, Shuxia [1 ]
Guo, Xiaoling [1 ]
Liu, Heze [1 ]
Gong, Zheng [1 ]
Sun, Xiaoxiang [1 ]
Wang, Hui [1 ,3 ]
Guo, Yu [1 ,3 ]
机构
[1] Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Hubei Province, Wuhan,430071, China
[2] Department of Pharmacy, Zhongnan Hospital of Wuhan University, Hubei Province, Wuhan,430060, China
[3] Hubei Provincial Key Laboratory of Developmentally Originated Disease, Hubei Province, Wuhan,430071, China
关键词
This work was supported by the National Natural Science Foundation of China (no. 81773812; 81703631; and; 82030111; National Key Research and Development Program of China (no. 2020YFA0803900 ); Outstanding Young Scholar Foundation of Hubei Province (no. 2017CFA055 ); and the Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University (no. TFJC2018001 );
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 24 条
  • [1] Prenatal dexamethasone exposure induced pancreatic β-cell dysfunction and glucose intolerance of male offspring rats: Role of the epigenetic repression of ACE2
    Dai, Yongguo
    Kou, Hao
    Gui, Shuxia
    Guo, Xiaoling
    Liu, Heze
    Gong, Zheng
    Sun, Xiaoxiang
    Wang, Hui
    Guo, Yu
    SCIENCE OF THE TOTAL ENVIRONMENT, 2022, 826
  • [2] Epigenetic repression of AT2 receptor is involved in β cell dysfunction and glucose intolerance of adult female offspring rats exposed to dexamethasone prenatally
    Kou, Hao
    Gui, Shuxia
    Dai, Yongguo
    Guo, Yu
    Wang, Hui
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 404
  • [3] Low expression programming of angiotensin receptor Ⅱ mediated pancreatic β cell dysfunction and glucose intolerance in prenatal dexamethasone-exposed female rats
    KOU Hao
    GUI Shu-xia
    DAI Yong-guo
    Guo Yu
    WANG Hui
    中国药理学与毒理学杂志, 2019, (10) : 757 - 758
  • [4] miR-148a/LDLR mediates hypercholesterolemia induced by prenatal dexamethasone exposure in male offspring rats
    Li, Li
    Hu, Wen
    Liu, Kexin
    Zhang, Dingmei
    Liu, Min
    Li, Xufeng
    Wang, Hui
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 395
  • [5] Age-Characteristic Changes of Glucose Metabolism, Pancreatic Morphology and Function in Male Offspring Rats Induced by Prenatal Ethanol Exposure
    Xiao, Di
    Kou, Hao
    Gui, Shuxia
    Ji, Zhenyu
    Guo, Yu
    Wu, Yin
    Wang, Hui
    FRONTIERS IN ENDOCRINOLOGY, 2019, 10
  • [6] Epigenetic programming of TBX2/CX43 mediates lower sperm quality in male offspring induced by prenatal dexamethasone exposure
    Liu, Yi
    Chen, Guanghui
    Wang, Hui
    TOXICOLOGICAL SCIENCES, 2023, : 178 - 193
  • [7] Lentivirus-delivered ACE siRNA rescues the impaired peak bone mass accumulation caused by prenatal dexamethasone exposure in male offspring rats
    Xiao, Hao
    Wen, Yinxian
    Wu, Zhixin
    Chen, Haitao
    Magdalou, Jacques
    Wang, Hui
    Chen, Liaobin
    BONE, 2020, 141
  • [8] Increased H3K27ac level of ACE mediates the intergenerational effect of low peak bone mass induced by prenatal dexamethasone exposure in male offspring rats
    Hao Xiao
    Yinxian Wen
    Zhengqi Pan
    Yangfan Shangguan
    Jun Qin
    Yang Tan
    Hongqiang Jiang
    Bin Li
    Qi Zhang
    Liaobin Chen
    Hui Wang
    Cell Death & Disease, 9
  • [9] Increased H3K27ac level of ACE mediates the intergenerational effect of low peak bone mass induced by prenatal dexamethasone exposure in male offspring rats
    Xiao, Hao
    Wen, Yinxian
    Pan, Zhengqi
    Shangguan, Yangfan
    Qin, Jun
    Tan, Yang
    Jiang, Hongqiang
    Li, Bin
    Zhang, Qi
    Chen, Liaobin
    Wang, Hui
    CELL DEATH & DISEASE, 2018, 9
  • [10] Stimulation of the ACE2/Ang-(1–7)/Mas axis in hypertensive pregnant rats attenuates cardiovascular dysfunction in adult male offspring
    Amanda S. M. Bessa
    Érika F. Jesus
    Allancer D. C. Nunes
    Carolina N. R. Pontes
    Ismaley S. Lacerda
    Jaqueline M. Costa
    Elisângela J. Souza
    Ruy S. Lino-Júnior
    Manoel F. Biancardi
    Fernanda C. A. dos Santos
    Gustavo R. Pedrino
    Diego B. Colugnati
    Renata Mazaro-Costa
    Elizabeth P. Mendes
    Carlos H. Castro
    Hypertension Research, 2019, 42 : 1883 - 1893