Preparation and properties of oxidized hyaluronic acid-hydroxypropyl chitosan self-healing hydrogel

被引：0
|
作者：
Wang Y. [1 ]
Qu M. [1 ]
Zhang H. [1 ]
Li Z. [1 ,2 ]
机构：
[1] School of Chemical Engineering and Materials, Tianjin University of Science and Technology, Tianjin
[2] State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai
来源：
Fuhe Cailiao Xuebao/Acta Materiae Compositae Sinica | 2023年 / 40卷 / 10期
关键词：
hydrogels; hydroxypropyl chitosan; oxidized hyaluronic acid; self-healing; sustained drug release;
D O I：
10.13801/j.cnki.fhclxb.20230207.001
中图分类号：
学科分类号：
摘要：
In this paper, oxidized hyaluronic acid (OHA) was synthesized by oxidizing hydroxyl groups on hyaluronic acid (HA) with sodium periodate. OHA/HPCS self-healing hydrogel was prepared by using OHA and hydroxypropyl chitosan (HPCS) as raw materials. The aldehyde group on OHA reacted with the amino group of HPCS to form dynamic imine bond through Schiff base reaction. In this paper, the microscopic morphology and properties of OHA/HPCS self-healing hydrogel was characterized by FTIR, UV-vis, SEM, rheology and 1H NMR. OHA/HPCS hydrogels have a porous structure, and the results show that the pore size ranged from 70 to 200 µm by changing the amount of OHA. With the increase of the dosage of OHA, the pores in the OHA/HPCS hydrogels increase, the pore size becomes smaller, the swelling ratio of OHA/HPCS becomes smaller, and the degradation rate becomes slower. OHA/HPCS hydrogel can self-heal within 4 h at room temperature without external stimulation. OHA/HPCS hydrogel can release anticancer drug of gemcitabine in sustained way, with a cumulative release percent of 70%-84% in 12 days. OHA/HPCS hydrogels have the properties of sustained release gemcitabine, indicating that OHA/HPCS hydrogels have potential application prospects in the field of drug release. © 2023 Beijing University of Aeronautics and Astronautics (BUAA). All rights reserved.
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页码：5884 / 5891
页数：7
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