Effect of biocompatibility on surface morphology of polyaniline/polylactic acid composite nanofibers

被引：0
|
作者：
Liu R. [1 ]
Zhang S. [1 ]
Huang X. [1 ]
Peng X. [1 ]
Min Y. [1 ,2 ]
机构：
[1] School of Materials and Energy, Guangdong University of Technology, Guangzhou
[2] Dongguan South China Design Innovation Institute, Dongguan
来源：
Huagong Jinzhan/Chemical Industry and Engineering Progress | 2021年 / 40卷 / 08期
关键词：
Biocompatibility; Polyaniline/polylactic acid composite nanofiber; Surface morphology; Tartaric acid doping;
D O I：
10.16085/j.issn.1000-6613.2020-1745
中图分类号：
学科分类号：
摘要：
Polyaniline (PANI) can regulate cell adhesion, proliferatio, and differentiation under the external electric field. However, the electrical activity of polyaniline based degradable nanofibers will be weakened because of PANI dedoped in the body physiological environment. Yet it could promote the cell adhesion, growth and proliferation. In this paper, tartaric acid was selected as the acid dopant in the in-situ polymerization of polyaniline on the surface of polylactic acid (PLA) nanofibers after plasma treatment. The effects of different morphologies of polyaniline/polylactic acid (PANI/PLA) composite nanofibers with the different molar ratio of tartaric acid to aniline at 1:1, 1:2 and 1:4 were investigated. The morphology and chemical composition of polyaniline were characterized by SEM, TEM and FTIR. The wettability was evaluated by contact angle. The biocompatibility of PANI/PLA composite nanofibers was evaluated by MTT, ALP and immunofluorescence staining. The results showed that the morphology of polyaniline with the molar ratio of tartaric acid to aniline at 1:1, 1:2, and 1:4 was nanoparticles, nanofiber and nano-hollow tubes, respectively. PANI attached to the surface of PLA nanofibers did not affect the porous structure of electrospinning. The surface wettability of PANI/PLA composite nanofibers was excellent, which was helpful for cell adhesion and growth. The biocompatibility of nanofiber polyaniline was better than that of nanoparticle polyaniline, and the effect of nano-hollow tubular polyaniline on biocompatibility was much better. © 2021, Chemical Industry Press Co., Ltd. All right reserved.
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页码：4406 / 4412
页数：6
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