Combined with the characteristics of high temperature and high humidity area, a new type of solar energy dehumidification air conditioning system was designed, and the indoor comfort of solar energy dehumidification air conditioning system was simulated by CFD software Airpak. The simulation were completed under the condition of the steady-state case and by using the method of comparative analysis to simulate the same room radiation air conditioning system of solar liquid desiccant and conventional primary return air conditioning system respectively. The comparative analysis used the data of the indoor thermal comfort, mainly including indoor temperature, humidity and wind speed. The results show that the simulation room 1 keeps basically around 26 ℃, relative humidity between 55%-55%, wind speed between 0.05-0.15 m/s within human activities region. The distribution of temperature and relative humidity is relatively uniform, with no sense of blowing and strong thermal comfort;And simulation room 2 keeps around 24℃, relative humidity between 40%-80%, wind speed between 0.3-0.5 m/s within human activities region, the uniformity of the distribution of temperature and relative humidity is poorer, with a sense of blowing and poor thermal comfort. The designed solar energy dehumidification air conditioning system indoor temperature, relative humidity and wind speed is distributed evenly, fluctuation is small and in the corresponding comfort zone. The indoor velocity field and indoor thermal environment are superior compared with that of traditional air conditioning system. It can overcome the application limits of the traditional liquid desiccant air conditioning system in hot and humid area, also it can sufficiently use the rich solar energy and other renewable energy sources in hot and humid areas, and provide a useful reference for the energy-saving transformation of air conditioning system in high temperature and high humidity areas. © 2019, Editorial Board of Acta Energiae Solaris Sinica. All right reserved.