Heterogeneous nucleation induced A. pernyi/B. mori silk fibroin coatings on AZ31 biometals with enhanced corrosion resistance, adhesion and biocompatibility

被引：0

作者：

Cao, Xinru ^{[1
]}

Chen, Yanning ^{[1
]}

Zhang, Chen ^{[1
]}

Mao, Zhinan ^{[2
]}

Zhang, Jingwu ^{[1
]}

Ma, Tingji ^{[1
]}

Tian, Wenhan ^{[3
]}

Kong, Xiangsheng ^{[1
]}

Li, Haotong ^{[1
]}

Rao, Sixian ^{[4
]}

Yang, Kang ^{[1
,4
]}

机构：

[1] School of Materials Science and Engineering, Anhui University of Technology, Maanshan,243002, China

[2] School of Materials Science and Engineering, Peking University, Beijing,100871, China

[3] International Research Center for Advanced Structural and Biomaterials, School of Materials Science and Engineering, Beihang University, Beijing,100191, China

[4] School of Mechanical Engineering, Anhui University of Technology, Maanshan,243002, China

来源：

International Journal of Biological Macromolecules | 2024年 / 264卷

基金：

中国国家自然科学基金;

关键词：

Biocompatibility - Cell adhesion - Corrosion resistant alloys - Corrosion resistant coatings - Crystallinity - Magnesium alloys - Nucleation - Organic coatings - Tissue regeneration;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Silk fibroin coatings on biomedical magnesium alloys have garnered significant attention due to their enhanced corrosion resistance and biocompatibility. However, the utilization of wild A. pernyi silk fibroin, known for its RGD sequence that facilitates tissue regeneration, presents a challenge for corrosion-resistant coatings on magnesium alloys due to its weak adhesion and high dissolution rate. In this study, we employed hexafluoroisopropanol as a solvent to blend A. pernyi silk fibroin with B. mori silk fibroin. The resulting blended fibroin coating at a 3:7 mass ratio exhibited a heterogeneous nucleation effect, enhancing β-sheet content (32.3 %) and crystallinity (28.6 %). This improved β-sheet promoted the labyrinth effect with an Icorr of 2.15 × 10−6 A cm−2, resulting in significantly improved corrosion resistance, which is two orders of magnitude lower than that of pure magnesium alloy. Meanwhile, the increased content of exposed serine in zigzag β-sheet contributes to a higher adhesion strength. Cell cytotoxicity evaluation confirmed the enhanced cell adhesion and bioactivity. This work provides a facile approach for wild A. pernyi silk fibroin coatings on magnesium alloys with enhanced corrosion resistance, adhesion and biocompatibility. © 2024 Elsevier B.V.

引用

共 2 条

[1] Heterogeneous nucleation induced A. pernyi / B. mori silk fibroin coatings on AZ31 biometals with enhanced corrosion resistance, adhesion and biocompatibility
Cao, Xinru
Chen, Yanning
Zhang, Chen
Mao, Zhinan
Zhang, Jingwu
Ma, Tingji
Tian, Wenhan
Kong, Xiangsheng
Li, Haotong
Rao, Sixian
Yang, Kang
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 264
[2] Hexafluoroisopropanol based silk fibroin coatings on AZ31 biometals with enhanced adhesion, corrosion resistance and biocompatibility
Li, Haotong
Si, Songhua
Yang, Kang
Mao, Zhinan
Sun, Yuehua
Cao, Xinru
Yu, Haotian
Zhang, Jingwu
Ding, Can
Liang, Hongxing
Wu, Liang
PROGRESS IN ORGANIC COATINGS, 2023, 184

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