Multi-Channel Brain Functional Imaging System Based on Lock-in Photon Counting

被引：0
|
作者：
Ding X. [1 ]
Wang B. [1 ]
Liu D. [1 ]
Zhang Y. [1 ]
Pan T. [1 ]
Gao F. [1 ,2 ]
机构：
[1] School of Precision Instruments & Opto-Electronics Engineering, Tianjin University, Tianjin
[2] Tianjin Key Laboratory of Biomedical Detection Technology and Instrumentation, Tianjin
来源：
Zhongguo Jiguang/Chinese Journal of Lasers | 2019年 / 46卷 / 01期
关键词：
Brain functional imaging technology; Diffuse optical tomography; Imaging system; Lock-in photon counting technology; Reference-weighted counting strategy; Scheme of 7-time excitation;
D O I：
10.3788/CJL201946.0107001
中图分类号：
学科分类号：
摘要：
Functional near-infrared spectroscopy imaging has become the preferred choice as a neuroimaging technique of brain function research. To obtain the imaging system with high sensitivity, large dynamic range and high temporal resolution, we develop a multi-channel near-infrared brain functional imaging system based on improved lock-in photon-counting. The light source module consists of 16 laser diodes with wavelength of 785, 808 and 830 nm, respectively, which are modulated by square wave with frequency space of 252 Hz. The detection module includes nine photon counting photomultiplier tubes. This system combines the ultra-high sensitivity of the photon-counting technology with the simple parallelism of the digital lock-in detection based on square wave modulation mode, and system performance meets requirements. The linear correlation coefficient can reach 0.9989, cross talk between channels is negligible. The system has strong anti-interference ability and the ability to locate accurately. © 2019, Chinese Lasers Press. All right reserved.
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