Development of nanoemulsions containing Lavandula dentata or Myristica fragrans essential oils: Influence of temperature and storage period on physical-chemical properties and chemical stability

被引:0
|
作者
Cossetin, Luciana Filippin [1 ]
Garlet, Quelen Iane [1 ]
Velho, Maiara Callegaro [2 ]
Gündel, Samanta [2 ]
Ourique, Aline Ferreira [2 ]
Heinzmann, Berta Maria [1 ]
Monteiro, Sílvia Gonzalez [3 ]
机构
[1] Department of Industrial Pharmacy, Faculty of Pharmacy, Federal University of Santa Maria, Santa Maria,Rio Grande do Sul State,97105-900, Brazil
[2] Nanotechnology Laboratory, Franciscana University, Santa Maria,Rio Grande do Sul State,97010-032, Brazil
[3] Department of Microbiology and Parasitology, Faculty of Veterinary Medicine, Federal University of Santa Maria, Santa Maria,Rio Grande do Sul State,97105-900, Brazil
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Essential oils are characterized as complex compound mixtures with important pharmacological properties, yet they are sensitive to high temperatures, light, and the presence of oxygen. Nanotechnology is therefore used to improve stability, securing both quality and efficacy. To evaluate the stability of Lavandula dentata Linnaueus and Myristica fragrans Houtt essential oils when associated with nanostructures, nanoemulsions containing 5% essential oil with hydrophilic and lipophilic surfactants were developed through emulsification under high agitation. Fabrication of the formulations did not qualitatively or quantitatively affect the majority of the essential oil compounds being identificates by gasose cromatografy as main constituents (-) - β-pinene (24–31 %), 1-terpinen-4-ol (14–15 %), L- α-pinene (13 %) and sabinene (10–15 %), in M. fragrans; e 1.8 cineol (50–52 %), fenchone (17−16 %) and camphor (15–13 %) for L. dentata. The systems were characterized in terms of average droplet size, polydispersity index, pH, zeta potential, and each essential oil's chemical composition (upon preparation), and for 90 days under the following storage conditions: refrigeration temperature, room temperature, and a controlled climatic chamber. After preparation: the droplet size of M. fragrans esential oil-loaded nanoemulsion (NE–MO) was 87.06 ɳm, its polydispersity index (PDI) was 0.17, the zeta potential value was -14.8 mV, and the pH was 5.62; L. dentata esential oil–loaded nanoemulsion (NE–LO) droplet size was 64.99 ɳm, its polydispersity index (PDI) was 0.26, zeta potential value was –11.1 mV, and the pH was 4.95. Investigation of these physicochemical response (particle size and polydispersity index) suggests that NE–MO presented intended responses and good stability over 3 months’ and 15 days storage at refrigeration and room temperature, respectively; being that the pH of formulation was maintained unaltered in the three conditions. Produced nanoemulsions with essential oil of Lavandula dentata presented physicochemical stables response in period of 3 months’ and 7 days torage at refrigeration and room temperature, respectively; but pH value was maintained unaltered only up to 15 days in refrigeration. Chemical analyses proved the greater efficacy of the NE–MO to preserve the majority compound percentages oil (L-α-pinene, (-)-β-pinene, sabinene, α-limonene, γ-terpinene) throughout the study under storage at 4 and 24 °C compared with free oil. The formulation NE–LO enabled good protection only at room temperature for α-pinene, sabinene 1.8-cineole, fenchone and camphor. However, this formulation not presented stables physicochemical characteristics during the study at room temperature. In summary, the nutmeg oil–loaded nanoemulsion was successfully formulated and its protection profile ensured essential oil chemical stability. © 2020 Elsevier B.V.
引用
收藏
相关论文
共 17 条
  • [1] Development of nanoemulsions containing Lavandula dentata or Myristica fragrans essential oils: Influence of temperature and storage period on physical-chemical properties and chemical stability
    Cossetin, Luciana Filippin
    Garlet, Quelen Iane
    Velho, Maiara Callegaro
    Gundel, Samanta
    Ourique, Aline Ferreira
    Heinzmann, Berta Maria
    Monteiro, Silvia Gonzalez
    INDUSTRIAL CROPS AND PRODUCTS, 2021, 160
  • [2] Chemical Composition and Insecticidal Properties of Moroccan Lavandula dentata and Lavandula stoechas Essential Oils Against Mediterranean Fruit Fly, Ceratitis capitata
    Ghalbane, Ichrak
    Alahyane, Hassan
    Aboussaid, Houda
    Chouikh, Nor-eddine
    Costa, Jean
    Romane, Abderrahmane
    El Messoussi, Said
    NEOTROPICAL ENTOMOLOGY, 2022, 51 (04) : 628 - 636
  • [3] Chemical Composition and Insecticidal Properties of Moroccan Lavandula dentata and Lavandula stoechas Essential Oils Against Mediterranean Fruit Fly, Ceratitis capitata
    Ichrak Ghalbane
    Hassan Alahyane
    Houda Aboussaid
    Nor-eddine Chouikh
    Jean Costa
    Abderrahmane Romane
    Said El Messoussi
    Neotropical Entomology, 2022, 51 : 628 - 636
  • [4] Studies on the changes of produced oils physical-chemical properties during development of Romashkinskoye field
    Hamidullin, FF
    Diyashev, RN
    Amerhanov, II
    NEFTYANOE KHOZYAISTVO, 2000, (07): : 31 - 33
  • [5] Chemical composition and antibacterial properties of microemulsion and microemulgel formulations containing Lavandula angustifolia Mill. essential oils
    Kayiran, Serpil Demirci
    Bolgen, Umay Merve Guven
    Cevikelli, Tilbe
    Kizilyildirim, Suna
    Yildir, Bedirhan
    Ferahoglu, Elif
    Kirici, Saliha
    Ozogul, Fatih
    INDUSTRIAL CROPS AND PRODUCTS, 2025, 226
  • [6] The uniqueness of isolation of nutmeg essential oil from nutmeg seeds (Myristica fragrans Houtt.) and its effects on physical and chemical properties
    Riyanto
    Umayah, Sri
    Marhaendro, Puthut
    INDIAN JOURNAL OF NATURAL PRODUCTS AND RESOURCES, 2021, 12 (02): : 247 - 255
  • [7] Chitosan-based films containing nanoemulsions of methyl salicylate: Formulation development, physical-chemical and in vitro drug release characterization
    da Silva, Talita Nascimento
    Reynaud, Franceline
    de Souza Picciani, Paulo Henrique
    de Holanda e Silva, Kattya Gyselle
    Barradas, Thais Nogueira
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 164 : 2558 - 2568
  • [8] Physical and chemical stability of β-carotene-enriched nanoemulsions: Influence of pH, ionic strength, temperature, and emulsifier type
    Qian, Cheng
    Decker, Eric Andrew
    Xiao, Hang
    McClements, David Julian
    FOOD CHEMISTRY, 2012, 132 (03) : 1221 - 1229
  • [9] Influence of polymeric surfactant structure and physical-chemical properties on the physical stability of an oil in water emulsion type agrochemical formulation
    Amado, Ricado Acosta
    Powels, Gregory
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [10] Nanodelivery of essential oils as efficient tools against antimicrobial resistance: a review of the type and physical-chemical properties of the delivery systems and applications
    Dupuis, Victoria
    Cerbu, Constantin
    Witkowski, Lucjan
    Potarniche, Adrian-Valentin
    Timar, Maria Cristina
    Zychska, Monika
    Sabliov, Cristina M.
    DRUG DELIVERY, 2022, 29 (01) : 1007 - 1024