Persteroid, a new steroid from the marine-derived fungus Penicillium sp. ZYX-Z-143

被引：0

作者：

Dai, Lu-Ting ^{[1
,2
,3
]}

Yang, Li ^{[1
,2
]}

Wang, Zi-Peng ^{[1
,2
]}

Guo, Jiao-Cen ^{[1
,2
]}

Ma, Qing-Yun ^{[1
,2
]}

Xie, Qing-Yi ^{[1
,2
]}

Dai, Hao-Fu ^{[1
,2
]}

Yu, Zhi-Fang ^{[3
]}

Zhao, You-Xing ^{[1
,2
]}

机构：

[1] Chinese Acad Trop Agr Sci, Haikou Key Lab Res & Utilizat Trop Nat Prod, Inst Trop Biosci & Biotechnol, Haikou, Peoples R China

[2] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Natl Key Lab Trop Crop Breeding, Haikou, Peoples R China

[3] Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2024年

关键词：

Penicillium sp; steroid; PTP1B; anti-inflammatory; cytotoxicity; antibacterial activity;

D O I：

10.1080/14786419.2024.2394834

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new steroid named persteroid (1) and seven known compounds (2-8) were isolated from the marine-derived fungus Penicillium sp. ZYX-Z-143. The structure of 1 was determined by HRESIMS, NMR, and ECD calculations. Compound 1 showed inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with IC50 value of 46.31 +/- 0.52 mu M. Moreover, compound 1 potently suppressed nitric oxide (NO) production on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. The cytotoxicity and antibacterial activity of all isolates were tested. [GRAPHICS]

引用

页数：8