Artificial Intelligence (AI)-Enhanced Detection of Diabetic Retinopathy From Fundus Images: The Current Landscape and Future Directions

Diabetic retinopathy (DR) remains a leading cause of vision loss worldwide, with early detection critical for preventing irreversible damage. This review explores the current landscape and future directions of artificial intelligence (AI)-enhanced detection of DR from fundus images. Recent advances in deep learning and computer vision have enabled AI systems to analyze retinal images with expert-level accuracy, potentially transforming DR screening. Key developments include convolutional neural networks achieving high sensitivity and specificity in detecting referable DR, multi-task learning approaches that can simultaneously detect and grade DR severity, and lightweight models enabling deployment on mobile devices. While these AI systems show promise in improving the efficiency and accessibility of DR screening, several challenges remain. These include ensuring generalizability across diverse populations, standardizing image acquisition and quality, addressing the "black box" nature of complex models, and integrating AI seamlessly into clinical workflows. Future directions in the field encompass explainable AI to enhance transparency, federated learning to leverage decentralized datasets, and the integration of AI with electronic health records and other diagnostic modalities. There is also growing potential for AI to contribute to personalized treatment planning and predictive analytics for disease progression. As the technology continues to evolve, maintaining a focus on rigorous clinical validation, ethical considerations, and real-world implementation will be crucial for realizing the full potential of AI-enhanced DR detection in improving global eye health outcomes.