Regioselective Halogenation of 2-Oxindoles and β-Keto Esters Using Oxone-Halide With or Without Aryl Iodine

Efficient and environmentally benign regioselective halogenation protocols have been achieved through the mediation of oxone-halide, with or without the assistance of aryl iodine. The key to the success of the regioselectivity process is the controlled generation of the active [X]+ or halogen-substituted hypervalent iodine (III) by manipulating the components of the oxone-halide-aryl iodine system. Environmentally friendly and regioselective halogenation protocols, especially green fluorination protocols of 2-oxindoles and beta-keto esters are developed by manipulation of the components of the oxone-halide-aryl iodine system. image