Background and Objective: There is a current research gap regarding the symptom structure and underlying causal relationships between complex posttraumatic stress disorder (CPTSD) and depressive symptoms. This longitudinal study used a cross-sectional network and cross-lag panel network (CLPN) to examine how CPTSD and depression symptoms interact over time in Chinese college students with childhood trauma.Methods: From 18,933 college students who took part in 2 surveys 12 months apart, 4006 participants (mean age: 20.07 +/- 2.04) who reported childhood trauma were screened. Within this sample, there were 2354 (58.8%) males and 1652 (41.2%) females.Results: In the one-year interval CLPN model, it was found that depressive symptoms may precede other symptoms. Specifically, negative emotions and negative self-evaluations are more likely to predict subsequent symptoms. Conversely, in CPTSD, symptoms related to fear and anxiety, such as avoidance, intrusion, and hyperarousal, are more frequently activated by other symptoms, including negative emotionsConclusions: This finding offers a novel perspective on the interplay between CPTSD and depression, extending the existing theory. From a clinical standpoint, the points of intervention for comorbidity between depression and CPTSD who have experienced childhood trauma differ across different stages. This study used network analysis to examine the evolving symptom structure of complex posttraumatic stress disorder (CPTSD) and depression, as well as the relationships between symptoms, in a large-scale longitudinal study among college students who have experienced childhood trauma.Symptoms such as emotional dysregulation and negative self-concept serve as stable central symptoms of both CPTSD and depression.Depression, tends to activate other symptoms, whereas CPTSD, is more frequently predicted by other symptoms. Antecedentes y objetivo: Existe una brecha en la investigaci & oacute;n actual sobre la estructura de los s & iacute;ntomas y las relaciones causales subyacentes entre el trastorno de estr & eacute;s postraum & aacute;tico complejo (TEPTC) y los s & iacute;ntomas depresivos. Este estudio longitudinal utiliz & oacute; una red transversal y una red de panel cruzado (CLPN por su sigla en ingl & eacute;s) para examinar c & oacute;mo interact & uacute;an el TEPTC y los s & iacute;ntomas de depresi & oacute;n a lo largo del tiempo en estudiantes universitarios chinos con trauma infantil.M & eacute;todos: De 18.933 estudiantes universitarios que participaron en dos encuestas con 12 meses de diferencia, se examin & oacute; a 4,006 participantes (edad media: 20.07 +/- 2.04) que informaron haber sufrido un trauma infantil. Dentro de esta muestra, hubo 2,354 (58.8%) varones y 1.652 (41.2%) mujeres.Resultados: En el modelo CLPN con un intervalo de un a & ntilde;o, se encontr & oacute; que los s & iacute;ntomas depresivos pueden preceder a otros s & iacute;ntomas. Espec & iacute;ficamente, las emociones negativas y las autoevaluaciones negativas tienen m & aacute;s probabilidades de predecir los s & iacute;ntomas posteriores. En cambio, en el TEPTC, los s & iacute;ntomas relacionados con el miedo y la ansiedad, como la evitaci & oacute;n, la intrusi & oacute;n y la hiperactivaci & oacute;n, se activan con mayor frecuencia por otros s & iacute;ntomas, incluidas las emociones negativas.Conclusiones: Estos hallazgos ofrecen una perspectiva novedosa sobre la interacci & oacute;n entre el TEPTC y la depresi & oacute;n, ampliando la teor & iacute;a existente. Desde un punto de vista cl & iacute;nico, los puntos de intervenci & oacute;n para la comorbilidad entre la depresi & oacute;n y el TEPTC en personas que han experimentado un trauma infantil difieren en las diferentes etapas.