Generation of integration-free human induced pluripotent stem cell line MURAi003-A derived from the peripheral blood mononuclear cells of a donor with homozygous Class I and Class II HLAs (A11:01, B46:01; C01:02; DRB109:01; DQB1*03:03)

被引：0

作者：

Pornratananont, Gunn ^{[1
]}

Tangprasittipap, Amornrat ^{[2
]}

Hongeng, Suradej ^{[3
]}

Anurathapan, Usanarat ^{[3
]}

机构：

[1] Mahidol Univ, Ramathibodi Hosp, Fac Med, Program Translat Med, Bangkok 10400, Thailand

[2] Mahidol Univ, Fac Med, Ramathibodi Hosp, Off Res Acad Affairs & Innovat, Bangkok 10400, Thailand

[3] Mahidol Univ, Ramathibodi Hosp, Fac Med, Dept Pediat, Bangkok 10400, Thailand

来源：

STEM CELL RESEARCH | 2024年 / 80卷

关键词：

POLYMORPHISM;

D O I：

10.1016/j.scr.2024.103514

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The human leukocyte antigen (HLA) system comprises cell-surface proteins responsible for the presentation of peptide antigens. HLAs play an essential role in the regulation of the human immune system, and their studies have been crucial to its understanding. To create a sustainable model for the investigation of HLAs, we successfully generated the human iPSC line MURAi003-A derived from the peripheral blood mononuclear cells of a donor with homozygous Class I and Class II HLAs (A*11:01, B*46:01; C*01:02; DRB1*09:01; DQB1*03:03) using non-integrative reprogramming episomes. MURAi003-A exhibited pluripotent stem cell characteristics with consistent demonstrations of pluripotency and expression of stem cell-associated markers.

引用

页数：5

Generation of integration-free human induced pluripotent stem cell line MURAi003-A derived from the peripheral blood mononuclear cells of a donor with homozygous Class I and Class II HLAs (A*11:01, B*46:01; C*01:02; DRB1*09:01; DQB1*03:03)

Generation of integration-free human induced pluripotent stem cell line MURAi003-A derived from the peripheral blood mononuclear cells of a donor with homozygous Class I and Class II HLAs (A11:01, B46:01; C01:02; DRB109:01; DQB1*03:03)